- Weight loss can be voluntary or involuntary, in the latter case appetite may be increased or decreased.
- drugs (see below)
- excessive physical activity
- malabsorption syndromes
- endocrine — hyperthyroidism, diabetes mellitus (uncontrolled), phaeochromocytoma)
- chronic systemic infections such as Tb, HIV, endocarditis
- chronic cardiopulmonary disease
- endocrine — e.g. Addison’s disease
- psychiatric — e.g. depression, eating disorders
- drugs — e.g. alcohol, amphetamines, appetite suppressants, cocaine,digoxin, L-dopa, metformin, NSAIDs, opiates.