- Easter Island (Papa Nui)
- If you are lucky enough to climb upto the extinct volcano Rano-Kau on Easter Island you will discover a plaque commemorating the discovery of Rapa-mycin. Found in the soil on Rapa Nui and originally marketed as an antifungal but had some side effects, most notably its potent immunosuppressive and antiproliferative properties.
- It is now used to prevent organ rejection in transplant patients (prevents activation of T cells and B cells by inhibiting interleukin-2), coronary stent coating (eliminates abnormal white cells) and is used in the treatment of autoimmune lymphoproliferative syndrome (ALPS). Also if you are lucky enough to be a mouse then it will increase your life expectancy, however due to its immunosuppressant proerties I wouldn’t go ordering it over the internet just yet. [Reference]
- It appears that chocolate rabbits are most likely to suffer from this trauma.
- One survey found that 59% of the 28,113 respondents preferred to eat chocolate rabbits starting with the ears, 33% indicated that they had no starting point preference, and 4% indicated that they started with the tail or feet. [Reference]
- Egg on a string sign refers to the cardiomediastinal silhouette seen in transposition of the great arteries. [Reference]
- Chocolate poisoning.
- It is an overdosage reaction to the xanthine alkaloid theobromine, but it is in other products including tea, cola beverages, and acai berries, not just chocolate.
- Median lethal (LD50) doses of theobromine in humans is 1000 mg/kg. In dogs it is 300mg/kg hence why chocolate can poison dogs. Symptoms include nausea, vomiting, diarrhoea, cardiac arrhythmias, seizures and eventually death.
- The amount found in highly refined chocolate candies or sweets (typically 1.4–2.1 g/kg) is much lower than that of dark chocolate or unsweetened baker’s chocolate (> 14 g/kg).
- Tularemia caused by the intracellular bacterium Francisella tularensis.
- There are varying strains of virulence. F. tularensis tularensis (Type A), which is found in lagomorphs (rabbits, hares and pikas) is highly virulent in humans and domestic rabbits. [Reference]
- See the CDC signs and symptoms for the varying Tularemia signs and symptoms.
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