- Parry is best remembered for his accurate description of the pathophysiology of ischaemic heart disease
- He was the first to establish a relationship between angina and coronary heart disease, and that the functional efficiency of the coronary arteries was more indicative than their structural integrity
- Described the concept that ischaemic heart disease resulted from energy demands of the myocardium, which the vascular system was unable to supply
- 1825: He was the first to write accounts of the condition now known as progressive hemifacial atrophy (Parry-Romberg syndrome – 1846); congenital idiopathic dilatation of the colon (Hirschprungs disease – 1886) and expopthalmic goitre (Graves disease – 1935)
‘The most dangerous state incidental to the human mind is a calm acquiescence in the accuracy and extent of its own attainments‘. – Parry CH
- Born 21 October 1755 Cirencester, England
- Cirencester Grammar School with Edward Jenner
- 1771 – Dissenters’ Academy, Warrington (Not Church of England, so unable to have Oxbridge education)
- 1778 – Medical doctorate, Edinburgh University
- 1779 – General Practitioner; physician to the Puerperal Charity Hospital and Casualty Hospital, Bath
- 1816 – Suffered a stroke in 1816 which left him with aphasia and right hemiplegia. With the assistance of his daughter, Parry edited his notes, cases and observations using his left hand to annotate.
- Died 9 March 1822
Key Medical Attributions:
- Following the death of Caleb Hillier Parry aged 66, his son Charles posthumously published his fathers case notes and writings in 1825 including further illuminating insights.
- Parry described 5 cases of exophthalmic goitre, predating the classical accounts which were subsequently published by Graves (1935) and von Basedow. Osler suggested the goitre be named Parry’s disease… [Parry CH, 1825 pp110-128]
- Parry described idiopathic dilatation of the colon preceeded Harald Hirschsprunng’s description at the Berlin Congress for Children’s Diseases in 1886. Parry’s description of ‘Hirschsprung’s disease‘ was in a male adult with chronic digestive disturbances. Autopsy revealed an enormously distended colon with no evidence of obstruction in the alimentary canal [Parry CH, 1825 pp380-386].
- Parry CH. An inquiry into the symptoms and causes of the syncope anginosa, commonly called angina pectoris : illustrated by dissections. 1799.
- Parry CH. Cases of tetanus, and rabies contagiosa, or canine hydrophobia. London: Underwoods 1814
- Parry CH. Elements of pathology and therapeutics. London: Underwoods 1815 [With incomplete Vol II posthumously presented 1825]
- Parry CH. An experimental inquiry into the nature, cause, and varieties of the arterial pulse. London: Underwoods 1816
- Parry CH. Collections from the unpublished medical writings of the late Caleb Hillier Parry. Vol I, Vol II London: Underwoods 1825.
- Graves S. Congenital idiopathic dilatation of the colon or Hirschprung’s disease. Ann Surg. 1918 Jun; 67(6): 734–737. [PMC1426734]
- Finney JMT. Congenital idiopathic dilatation of the colon. Surg., Gyn. and Obst., igo8, vi, 624.
- Biography: Caleb Hillier Parry Munk’s Roll: Volume II
- Hull G. Caleb Hillier Parry 1755-1822: a notable provincial physician. J R Soc Med. 1998 Jun; 91(6): 335–338. [PMC1296785]
- Fye WB. Caleb Hillier Parry. Clin Cardiol. 1992 Aug;15(8):619-21. [PMID 1499192]
- Rolls R. Caleb Hillier Parry (1755-1822). JLL Bulletin: Commentaries on the history of treatment evaluation. 2003
- Larner AJ. Caleb Hillier Parry (1755-1822): clinician, scientist, friend of Edward Jenner (1749-1823). J Med Biogr. 2005 Nov;13(4):189-94. [PMID 16244710]
LITFL Related Links
- Biographical Medical Eponyms – A-Z of eponymous medical pioneers
- Eponymictionary – Searchable Eponymictionary Database
- Medical Eponyms – A-Z of signs, syndromes, diseases and classifications
- Orthopaedic Eponyms – Eponymous orthopedic fractures and classifications
- Cardiac Eponyms – Eponymous cardiology collection