- Hartmann developed a technique to measure sugar in patients’ blood whilst still at medical school – a significant step towards the discovery of insulin.
- Hartmann also created a fluid and electrolyte replacement therapy for infants universally known as Lactated Ringer’s solution, or Hartmann’s Solution.
- In 1932, modified Ringer’s solution by adding sodium lactate to it with the idea of combating acidosis in his young patients.
- Born 1898, St Louis, Missouri
- 1921 – Graduated Washington University School of Medicine in St Louis
- Died 1964
Key Medical Attributions:
- His interest in childhood diabetes and research led to the 1932 publication of two studies that showed differences in serum electrolyte patterns in dehydration and described the use of the solution to treat acidosis in children.
- Hartmann influenced Carl and Gerty Cori by recommending that they study glucose-6-phosphatase in glycogen storage disease – groundbreaking work that eventually earned them the Nobel Prize in Physiology or Medicine in 1947
- Hartmann’s Solution – Synonyms: compound sodium lactate, sodium lactate solution, Ringer-Locke’s solution, Ringer-lactate, lactated Ringer’s solution (LRS)
- Schaffer-Hartmann Method – for true blood glucose analysis
- Shaffer PA, Hartmann AF. The Iodometric Determination of Copper and its Use in Sugar Analysis. I. Equilibria in the Reaction Between Copper Sulfate and potassium iodide. J. Biol. Chem. 1921 45: 349-. [Full Text]
- Pennoyer MM, Hartmann AF Sr. Management of infants born of diabetic mothers. Postgrad Med. 1955 Sep;18(3):199-206. [PMID 13254545]
- Hartmann AF, Senn MJE. Studies in the metabolism of sodium r-lactate. I. Response of normal human subjects to the intravenous injection of sodium r-lactate. J Clin Invest. 1932 Mar; 11(2): 327–335. [PMC435816]
- Hartmann AF, Senn MJE. Studies in the metabolism of sodium r-lactate. II. Response of human subjects with acidosis to the intravenous injection of sodium r-lactate. J Clin Invest. 1932 Mar; 11(2): 337–344. [PMC435817]
- Hartmann AF, Senn MJE. Studies in the metabolism of sodium r-lactate. III. Response Of Human subjects with liver damage, disturbed water and mineral balance, and renal insufficiency to the intravenous injection of sodium r-lactate. J Clin Invest. 1932 Mar; 11(2): 345–355. [PMC435817]
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