Dilated Cardiomyopathy Overview
- Dilated cardiomyopathy (DCM) is a myocardial disease characterised by ventricular dilatation and global myocardial dysfunction (ejection fraction < 40%).
- Patients usually present with symptoms of biventricular failure, e.g. fatigue, dyspnoea, orthopnoea, ankle oedema.
- Associated with a high mortality (2-year survival = 50%) due to progressive cardiogenic shock or ventricular dysrhythmias (sudden cardiac death).
Causes of Dilated Cardiomyopathy
- Dilated cardiomyopathy commonly occurs following massive anterior MI due to extensive myocardial necrosis and loss of contractility.
- Most cases are idiopathic.
- Up to 25% are familial (primarily autosomal dominant, some types are X-linked) .
A very small proportion may occur with:
- Viral myocarditis (coxsackie B / adenovirus).
- Toxins (e.g. doxorubicin).
- Autoimmune disease.
- Pregnancy (peripartum cardiomyopathy).
ECG Features of Dilated Cardiomyopathy
- The most common ECG abnormalities are those associated with atrial and ventricular hypertrophy — typically, left sided changes are seen but there may be signs of biatrial or biventricular hypertrophy.
- Interventricular conduction delays (eg. LBBB) occur due to cardiac dilatation.
- Diffuse myocardial fibrosis may lead to reduced voltage QRS complexes, particularly in the limb leads. There may be a discrepancy of QRS voltages with signs of hypertrophy in V4-6 and relatively low voltages in the limb leads.
- Abnormal Q waves are most often seen in leads V1 to V4 and may mimic the appearance of a myocardial infarction (“pseudoinfarction” pattern).
Common ECG associations with DCM
- Left atrial enlargement -> may progress to atrial fibrillation.
- Biatrial enlargement
- Left ventricular hypertrophy or biventricular enlargement
- Left bundle branch block (RBBB can also occur).
- Left axis deviation.
- Poor R-wave progression with QS complexes in V1-4 (“pseudo-infarction” pattern).
- Frequent ventricular ectopics and ventricular bigeminy (seen with severe DCM).
- Ventricular dysrhythmias (VT / VF).
Ischaemic dilated cardiomyopathy:
- There is marked LVH (S wave in V2 > 35 mm) with dominant S waves in V1-4.
- Right axis deviation suggests associated right ventricular hypertrophy (i.e. biventricular enlargement).
- There is evidence of left atrial enlargement (deep, wide terminal portion of the P wave in V1).
- There are peaked P waves in lead II suggestive of right atrial hypertrophy (not quite 2.5mm in height).
This patient had four-chamber dilatation on echocardiography with severe congestive cardiac failure (awaiting cardiac transplantation).
Idiopathic dilated cardiomyopathy:
- There is evidence of left ventricular hypertrophy with large precordial voltages and an LV strain pattern in leads with a dominant R wave (I, II, V6).
- There is also evidence of biatrial enlargement in V1 with a peaked initial portion of the P wave (RAE) followed by a deep terminal negative portion (LAE).
- The changes of right ventricular hypertrophy are masked by left ventricular dominance; however, this patient had four-chamber dilatation on echocardiography.
- There is marked left ventricular hypertrophy with repolarisation abnormality (LV “strain” pattern) in V5-6.
- LV dilatation has produced an interventricular conduction delay mimicking LBBB — however, this is not LBBB as the morphology is not typical and there are small Q waves in V5-6 (the presence of Q waves in V6 rules out LBBB).
- There are some signs of left atrial enlargement — leftward deviation of the P wave axis (positive P waves in I and aVL, inverted in III and aVF) and prolongation of the terminal portion of the P wave in V1.
- Right axis deviation in the presence of LVH suggests the possibility of biventricular enlargement.
- The widespread downsloping ST depression may be due to LVH (= “appropriate discordance”) or digoxin effect (a commonly used mediation in congestive cardiac failure).
- Brady WJ, Truwit JD. Critical Decisions in Emergency and Acute Care Electrocardiography
- Hampton, JR. The ECG In Practice, 6e
- Surawicz B, Knilans T. Chou’s Electrocardiography in Clinical Practice: Adult and Pediatric, 6e
- Wagner, GS. Marriott’s Practical Electrocardiography 12e
- Chan, TC. ECG in Emergency Medicine and Acute Care
- Mattu, A. ECG’s for the Emergency Physician
LITFL Further Reading
- ECG BASICS — Waves, Intervals, Segments and Clinical Interpretation
- ECG A to Z by diagnosis –alphabetical diagnostic approach to the ECG
- ECG CLINICAL CASES — ECG’s placed in clinical context with a challenging Q&A approach
- 100 ECG Quiz — Self-assessment tool for examination practice
- ECG Reference SITES and BOOKS — the best of the rest
- LITFL ECG IMAGE Database — Searchable database of LITFL ECG’s
- ECG and Cardiology Eponymous Syndromes — Cheats guide to eponymous emancipation
- ECG Exam Template — a framework for answering ECG exam questions.