Sotalol

CLASS

• anti-arrhythmic

MECHANISM OF ACTION

• low doses = non-selective beta receptor antagonist
• high doses = prolongs action potential

PHARMACEUTICS

• oral tablet

DOSE

• 240-320mg bd

INDICATIONS

• SVT
• VF
• AF

ADVERSE EFFECTS

• prolongation of QT interval
• torsades de pointes
• decreased myocardial contractility
• bradycardia
• bronchospasm (not recommended in asthma)

PHARMACOKINETICS

• Absorption –
• Distribution – no protein binding
• Metabolism – no metabolism
• Elimination – renal