- Give 10 mg/kg orally 3 times per day for 5 days. Then….
- Give 10 mg/kg orally 2 times per day for 14 days.
- Blood levels are followed after completion of this initial course.
- In those that are critically unwell the use of sodium calcium edetate is recommended.
- Adverse reactions include gastrointestinal upset, transient liver function abnormalities in 60% and reversible neutropenia.
- Bradberry S, Vale A. Dimercaptosuccinic acid (succimer; DMSA) in inorganic lead poisoning. Clinical Toxicology 2009; 47; 617-631.
- Dietrich KN, Ware HH, Salganik M et al. Effect of chelation on the neuropsychological and behavioral development of lead-exposed children after school entry. Pediatrics 2004; 114:19-26.
- Treatment guidelines for lead exposure in children. Committee on Drugs. Pediatrics 1995; 96: 155-160.