March 11, 2010

Elbow Dislocation

Elbow dislocations constitute 10% to 25% of all injuries to the elbow. The elbow is one of the most commonly dislocated joints in the body, with an average annual incidence of acute dislocation of 6 per 100,000 persons. Among injuries to the upper extremity, dislocation of the elbow is second only to dislocation of the shoulder.

Simple or Complex

Simple dislocations are described by the direction of the dislocated ulna. Posterior or posterolateral displacement of the ulna relative to the distal humerus is the most common simple dislocation with approximately 90% occurring this way (see image ). Rarer injuries include lateral and anterior displacements of the forearm.

When larger intra-articular fractures of the radial head, olecranon, or coronoid process occur with elbow dislocation, the injury is termed a complex dislocation.  Complex dislocations are much less common than simple dislocations. The risk of recurrent or chronic instability and posttraumatic arthrosis is increased significantly with complex dislocation.

Anterior Elbow Dislocation 590x438 Elbow Dislocation

AP and lateral Anterior Elbow Dislocation

Anatomy

The elbow joint  is one of the most inherently stable articulations. This stability is provided by the osseous and articular components with the shape and contour of the ulnohumeral articular surface providing anterior-posterior stability, varus/valgus, and rotatory stability. The capsuloligamentous components, which include the medial and lateral collateral ligaments and joint capsule, provide further stability by completing a structural ring about the elbow joint. Disruption of this ring is leads to elbow dislocation.

Elbow Ring 590x384 Elbow Dislocation

Finally the musculotendinous components, which include the muscles crossing the elbow joint, also contribute to the stability.

Lateral XR of Posterior Elbow Dislocation

Lateral XR of Posterior Elbow Dislocation

AP XR of Posterior Elbow Dislocation

AP XR of Posterior Elbow Dislocation

Evaluation

Patients present following a traumatic injury with swelling and deformity about the elbow. The mechanism of injury is usually a fall onto an outstretched hand.

TIP:  Elbow dislocation is sometimes confused with a supracondylar fracture. The two may be distinguished clinically by palpating for the equilateral triangle formed by the olecranon and epicondyles. This will be undisturbed in supracondylar fractures but distorted in elbow dislocations.

Neurovascular injury is uncommon, but should always be sought. Clinical evaluation should include median and ulna nerve function. Damage to the brachial artery can be assessed by palpating for a radial pulse.

After a complete examination, AP and lateral X-Rays of the elbow should be examined to determine the direction of the dislocation and to identify any associated fractures.

Evaluation of the Elbow dislocation

Clinical Evaluation of the Elbow dislocation

Management

Reduction can usually be carried out in the emergency department. It requires adequate muscular relaxation and appropriate analgesia. A fair amount of force is often required. Reduction may be achieved by correction of the medial or lateral displacement followed by strong traction on the forearm in the line of the limb. The arm may enlocate at this stage with a characteristic and satisfying reduction ‘clunk’. If not, firm pressure is applied posteriorly to the olecranon to bring it distally and anteriorly around the humeral trochlea. Traction should be maintained with the arm in moderate flexion, using counter-traction with the fingers. (see fig) Again a palpable ‘clunk’ will confirm reduction. Palpation should ensure the equilateral triangle formed by the olecranon and epicondyles is present.

TIP: After reduction, the elbow should be taken through a range of motion to evaluate joint stability. The elbow should be slowly extended and the angle at which tendency to redislocation occurs should be recorded. Most dislocated elbows are unstable to valgus stress (best tested in pronation to lock the lateral side).

Elbow relocation 1 Elbow Dislocation

X-Rays should then be performed in two planes, AP and lateral to ensure the reduction is concentric. Widening of the joint space may indicate entrapped osteochondral fragments. These patients should be referred to Orthopaedics for surgical debridement.

Note: Although X-Rays reveal periarticular fractures in 12% to 60% of cases, surgical exploration documents unrecognized osteochondral injuries in nearly 100% of acute elbow dislocations. Fortunately, the vast majority do not require operative intervention.

If the reduction is concentric and the joint is stable, the elbow should be splinted in 90 degrees of flexion. Patients should be followed up in 3-5 days with repeat X-rays to check reduction.

Enlocation 590x442 Elbow Dislocation

Complex dislocations

Complex elbow dislocation consists of both ligamentous and bony injuries. When one of the osseous or articular component structures of the elbow is disrupted, the risk of recurrent instability and arthrosis is greatly increased. Early mobilization of simple dislocations after closed reduction is associated with low risk of redislocation. These injuries, are more difficult to treat, and often have poorer results than simple dislocation. Fortunately they are much less frequent.

The radial head and coronoid process are the most commonly fractured structures in these injuries. Other structures that can be damaged include: medial and lateral collateral ligaments; medial and lateral condyles/epicondyles; transolecranon fractures and; posterior Monteggia fractures.

This disrupts the structural ring which provides stability to the elbow joint (see figure above). If there is evidence of disruption of one component of the ring, a second disruption is likely.

Note: The terrible triad consists of dislocation with associated radial head and coronoid process fracture.

Complex dislocations should have the same initial treatment- with clinical evaluation and reduction- as simple dislocations. They should all be referred to the inpatient Orthopaedic Surgery team for ongoing management, as they will require surgical repair.

Author Credit: Dr W G Blakeney

Podcasts for Emergency Physicians

podcast Podcasts for Emergency Physicians

What are podcasts?

The word ‘podcast’ is the bastard offspring of broadcasting and iPod. Podcasts are a series of digital media files, either audio or video (aka vodcasts), that are downloaded automatically by subscription to a feed.

Podcasts can be accessed over the web with most types of media playing software. They can be made with free software and hosted by free online services.

You don’t need an iPod to use podcasts!

Upside

  • Most podcasts are in audio format, which is great for auditory learners (probably about 30% of us), although there are also a plenty of vodcasts for visual learners too.
  • Users can listen to podcasts “on the go” with a portable device – anytime, anywhere – which maximizes time efficiency.
  • Many podcasts have free subscriptions.
  • Podcasts can be made with free software.
  • It is easy to subscribe to podcasts using a feed, or alternatively using iTunes.

Downside

  • Podcasts can vary in sound and video quality depending on the “amateurism/professionalism” of the podcast creator.
  • Sadly not all podcasts are free.
  • Media file downloads may require substantial bandwidth.
  • Podcasts lack “two-way” interaction and audience participation.
  • Once released and downloaded a podcast ‘episode’ can’t be modified or improved upon.

Recommended podcasts for Emergency Physicians

If you use iTunes, most of these podcasts can be found and freely subscribed to by searching the iTunes store. If you know of any other quality emergency medicine podcasts please let us know by commenting on this post or via twitter (@precordialthump or @sandnsurf).

Other links

[Last updated: 5 September 2009]

Academic Earth Open Source Lecture Series


academicearth22 Academic Earth Open Source Lecture Series

Academic Earth aims to give everyone on earth open access to a world-class education. They have built a ‘user-friendly educational ecosystem’ that allows internet users all around the globe to easily find, interact with, and learn from full video courses and lectures from the world’s leading scholars.

The interface is slick, the content high quality and the open source platform an excellent initiative. The site, now in Beta version, is expected to launch by the beginning of April with an onslaught of new features being added over the next six months according to Academic Earth’s CEO and founder Richard Ludlow in an article on the Bivings Report.

Our goal is to bring the best content together in one place and create an environment that in which that content is remarkably easy to use and in which user contributions make existing content increasingly valuable.

User feedback is paramount to the usability and functionality of this resource. Academic Earth is developing a ’social network’ around the lecture content to allow users to interact with professors and other students, make suggestions and complaints, and organize their own course load. The website received 100,000 visitors in its first 16 days, and has already responded to initial user feedback by creating shorter and more digestible lecture content, dividing the longer lectures into a series of posts.

academicearth1 Academic Earth Open Source Lecture Series

Currently Academic Earth has collated over fifteen hundred videos from MIT, Stanford, Berkeley, Harvard, Princeton, and Yale and hopes to include content from schools in the United Kingdom and other international universities to increase diversity and provide foreign language content. Subjects currently available include Astronomy, Biology, Chemistry, Computer Science, Economics, Engineering, English, Entrepreneurship, History, Law, Mathematics, Medicine, Philosophy, Physics, Political Science, Psychology and Religion.

Lecture content for each subject is often grouped into courses, which each contain anywhere from 4 to 50 lectures and in many cases can be downloaded to iPod in a Quicktime version. Each lecture or lecture series provides an overview of the lecture, course description and related resources such as powerpoint slides, citation information and transcripts. The quality of the sound and image for the majority of videos is excellent and the related resources add a bonus dimension.

To get the most from the Academic Earth experience it is best to create a profile. This allows you to add videos to ‘favorites’; provide feedback; rate lectures and be part of the site development.

academic earth lecture layout Academic Earth Open Source Lecture Series

As more and more high quality educational content becomes available online for free, we ask ourselves, what are the real barriers to achieving a world class education? We invite those who share our passion to explore our website, participate in our online community, and help us continue to find new ways to make learning easier for everyone – Academic Earth

Medical Update Australia

medicalupdate Medical Update Australia

Introducing a new website ‘Medical Update‘ designed to provide Australian medical practitioners with free virtual access to educational conferences and meetings has launched. Medical Update Pty Ltd director Gary Smith said video and power point slides from events from around the country are uploaded on to the site – MedicalUpdate.com.au – where they are easily accessible by subscribers.

Medical Update films educational meetings and conferences that doctors would normally attend and then place the visual learning material up on line. The site has been live since October and currently includes presentations from local and international clinicians covering a variety of topics including eating disorders, cardiology and ophthalmology.

The service should be an innovative and time-saving eLearning portal for clinicians, and is provided free to Australian medical practitioners who register online.

The website allows them to watch video of the conferences and meetings online at home or work, instead of spending hours at a meeting. We travel the country searching for the best presenters on the most interesting topics. We record the events (including PowerPoint slides) and make them available free of charge so you can watch them when it’s convenient for you. You get to stay up to date, without physically attending the meeting ( and so save hours of your time).

Courtesy of HealthEngine Australia

Health Sciences Online

healthservicesonline Health Sciences Online

Health Sciences Online (HSO) has launched claiming to be a ‘virtual learning center’ which aims to deliver authoritative, comprehensive, free, and ad-free health sciences knowledge using the search technology of Vivisimo. HSO (www.hso.info) is a portal with browse and search functions with access to a comprehensive collection of top-quality courses and references in medicine, public health, pharmacy, dentistry, nursing, basic sciences, and other health sciences disciplines.

The user is able to search any health sciences topic from over 50,000 courses, references, guidelines, and other learning resources. Source material is selected from accredited educational sources including universities, governments, and professional societies. These resources are hand-selected from already-existing reliable sources and resource collections by clinicians and other experts from medical specialty societies, accredited continuing education organizations, governments, and universities such as Cambridge, Columbia, Harvard, Hopkins, McGill, MIT, Penn, Stanford, and Yale.

hso2 300x79 Health Sciences Online

The information is delivered by powerful search technology from Vivisimo which allows users to easily see comprehensive search results and quickly find the answers they need. I really like the intuitive graphic interface for browsing and refining search; the Google Translator integration (covering 22 languages) and the ‘preview’ section in the search results. The preview tool allows the user to review the source site and associated information from withtin the results page.

hso 1 Health Sciences Online

Has this changed the face of health information provision forever? Certainly it is one of the most altruistic and honorable health service resources on the planet and will enhance information provision to a huge number of health care professionals worldwide. It appears to have succeeded in addressing the need for accessible, selective and current online educational/training resources to promote appropriate care and policies. Read this great review from AltSearchEngines.

HSO is an incredible resource for health professionals all over the world. Open access to health information should literally save millions of lives and lead to important new discoveries - Anne Margulies [Executive Director of Open Course Ware - MIT].

HSO is a not-for profit organization with primary funding partners including CDC, World Bank, the American College of Preventive Medicine, the World Health Organization, NATO’s Science for Peace Program, Annenberg Physician Training Program and the Ulrich and Ruth Frank Foundation for International Health.

HSO has succeeded where other initiatives have not, because our vision of a democratization of health sciences knowledge has tremendous appeal to a wide variety of supporters. This ranges from an endocrinologist who donated $50,000 because “HSO will change the world”, to an Armenian specialist in preventive medicine who volunteered more than 1,000 hours because “HSO will finally make top-quality information available to all the world’s doctors”, to Senator Sam Nunn’s Global Health and Security Initiative stating that, “HSO has abundant high quality resources, so it’s not like putting in keywords in a normal search engine – this will create revolutions in health education, disease surveillance, and telemedicine.”

embedded by Embedded Video

YouTube Direkt

HSO’s next phase will be developing programs using the gathered materials to help train and educate public and clinical health providers around the world.

Sharpen your brain with Medical Grand Rounds

117608281

Thanksto Alvaro Fernandez of SharpBrains for hosting a fantastic medical Grand Rounds:

Grand Rounds 5:12 – Healthcare Reform Q&A

Read on topics ranging from health insurace, attitude, training and mental health to patient outreach, technology and innovation… thanks Alvaro for hosting a great Grand Rounds

Venous Thromboembolism – Lecture Notes

Aetiology: Venous Thromboembolism

  • Acute provoking risk factors: hospitalisation, surgery, trauma or fracture of lower limbs or pelvis, immobilisation incl plaster cast, long haul travel, recent oestrogen therapy in last 2 weeks, IV device such as cannula.
  • Chronic predisposing factors: Inherited: Protein C, S, antithrombin III deficiency, Factor V Leiden, Prothrombin gene 20210A mutation.
  • Chronic predisposing factors: Acquired: Age, obesity, cancer, leg paralysis, oestrogen, pregnancy or puerperium, major medical illness (incl cardioresp disease, IBD, nephrotic syndrome, myeloproliferative disorder), previous VTE.
  • Chronic predisposing factors: Inherited or acquired: high plasma homocysteine, high coagulation factor VIII, IX, XI, antiphospholipid (anticardiolipin) antibody.

Diagnosis: Deep Vein Thrombosis (DVT)

Wells Clinical Model to predict pretest probability. Each feature scores + 1, except final one that scores – 2:

  • Active cancer with treatment, including palliative, in last 6 months; paralysis, paresis or recent plaster immobilisation of legs; bedridden for > 3 days or major surgery within last 12 weeks; localised tenderness along distribution deep venous system; entire leg swollen; calf swelling > 3 cm compared to normal measured 10 cm below tibial tuberosity; pitting oedema greater in symptomatic leg; non-varicose, collateral superficial veins; previous documented DVT; alternative diagnosis at least as likely DVT (NB carries negative 2 score).
  • Score ≥ 3 = high (53% prevalence); score 1-2 = moderate (17% prevalence) and score ≤ 0 = low (5% prevalence) pretest probability.

Diagnostic approach in patients with suspected DVT is then based on above pretest probability score, use of compression ultrasound and D-dimer:

  • Pretest probability low: perform D-dimer and if negative, rules out. If D-dimer positive, perform compression ultrasound (USS) proximal leg veins. If USS negative – rules out. If USS positive, treat.
  • Pretest probability moderate or high: perform USS. If normal, perform D-dimer and if negative, rules out. If D-dimer positive, repeat USS in one week, and if still normal – rules out.
  • Pretest probability moderate or high: perform USS and if abnormal, treat (and if abnormal at one week – see above).

Wells P, Owen C et al. Does this patient have deep vein thrombosis? JAMA 2006; 295:199-207. [Reference]

Treatment (of DVT)

  • Low molecular weight heparin (LMWH) SC for 5-7 days. Preferred to IV unfractionated (UFH). Use enoxaparin 1mg/kg BD. LMWH is easier to administer, no blood testing, smoother therapy with less treatment failures (or overtreatment), less risk of bleeding, less heparin-induced thrombocytopenia (HIT). Initiate warfarin and continue for 3-6 months.
  • Or can give enoxaparin 1.5mg sc once daily, but BD is preferred if high risk such as iliac vein thrombosis, obese or have cancer.
  • UFH iv is alternative for 5-7 days aiming for APTT 1.5 – 2.5 (avoid subtherapeutic values), plus warfarin initiated as above.
  • Fondaparinux new synthetic pentasaccharide that binds antithrombin and enhances activity towards Factor Xa, but not to thrombin. As effective as LMWH in DVT and UFH in treating PE.
  • Calf-vein DVT alone may be treated with outpatient LMWH for 1 week then a repeat USS. If no propagation (80%), stop treatment but continue with support stockings and repeat USS at 10-14 days. If propagated at either time, continue heparin another 4-5 days whilst commencing warfarin for 3-6 months.
  • Alternatively, calf-vein DVT may go untreated, with repeat USS to exclude propagation above knee (20%) at 1 week, and also at 10-14 days. If negative, no further action but recommend stockings and aspirin for ‘at risk’ times such as prolonged travel.

Blann A, Lip G. Venous thromboembolism. BMJ 2006;332:215-9. [Reference]

Ho WK, Hankey G. Venous thromboembolism: diagnosis and management of deep venous thrombosis. MJA 2005;182:476-81. [Reference]

Pulmonary Embolism

Clinical features:

  • Important PE symptoms are dyspnoea (73%), chest pain (66% – not always pleuritic), cough (37%), apprehension, sweating, haemoptysis and syncope.
  • Important signs are tachypnoea > 20/min (70%), crepitations (51%), tachycardia (30%), low grade fever.
  • Important laboratory findings are atelectasis or parenchymal abnormality on CXR, PaO2 under 80 mmHg in absence of lung disease.
  • ECG: sinus tachycardia common; AF, RAD, RBBB. Note S1Q3T3 is neither sensitive nor specific.
  • Absence of dyspnoea plus tachypnoea > 20 / min has a negative predictive value (NPV) for a PE of 90%; absence of these and pleuritic pain has NPV of 97%; with absence of CXR changes or low PaO2 as well in the remainder virtually excludes PE.

Corris P. A practical approach to the diagnosis of venothromboembolism. Clinical Medicine 2001; 1:274-280 [Reference]

Pretest Probability (PTP)

  • Use Wells’ Clinical Decision Rule to predict pretest probability (points in brackets):
  • Clinical signs and symptoms of DVT (3 points); alternative diagnosis less likely (3 points); heart rate above 100/min or immobilisation (or surgery) in last 4 weeks or previous DVT or PE (all 1.5 points); haemoptysis or malignancy (both 1 point).
  • Score > 6 = high (67% prevalence); score 2-6 = moderate (20.5% prevalence) and score < 2 = low (3.6% prevalence) pretest probability.

Diagnostic investigations

  • Stratified by pretest probability (PTP) and presence or absence of cardiorespiratory disease.
  • Low PTP. Perform D.dimer. If negative, rules out PE. If positive proceed to further testing – see below
  • Moderate or high PTP. Proceed to CTPA or isotope lung V/Q scan (consider V/Q especially if CXR normal):
    • Normal – excludes diagnosis (NPV > 96%).
    • High probability – treat (PPV 86-96%), unless contraindications to heparin.
    • Non-diagnostic – proceed to USS to define source of embolism in legs. Treat any positive. If negative, repeat USS. If positive, treat. If remain negative, no PE.

Kelly J, Hunt B. Role of D-dimers in diagnosis of venous thromboembolism. Lancet 2002; 359:456 458. [Reference]

Recent ‘dichotomous decision rule‘ has been validated, using just two Wells’ PTP categories, D.dimer and multislice CTPA only (‘Christopher Study’):

  • Wells’ Clinical Decision Rule (CDR) to predict pretest probability score ≤ 4 = ‘unlikely’, and score > 4 = ‘likely’.
  • CDR score unlikely (≤ 4), perform D.dimer and if negative, rules out = no PE. If D.dimer positive, perform CTPA. If CTPA negative rules out, if positive, treat.
  • CDR score likely (> 4), CTPA. If negative, rules out. If positive, treat.

Writing Group for the Christopher Study Investigators. Effectiveness of managing suspected pulmonary embolism using an algorithm combining clinical probability, D.dimer testing, and computed tomography. JAMA 2006;295:172-79. [Reference] (Editorial Hull RD. JAMA 2006;295:213-15). [Reference]

Righini M, Le Gal G, Aujesky D et al. Diagnosis of pulmonary embolism by multidetector CT alone or combined with venous ultrasonography of the leg: a randomised non-inferiority trial. Lancet 2008;371:1343-52. [Reference] (Editorial Kyrle P, Eichinger S. Lancet 2008;371:1312-15). [Reference] NB: validated Christopher Study findings.

Collapsed or hypotense (shocked) patient with high PTP:

  • Urgent echo (ideally TOE) and give thrombolysis if positive. If nondiagnostic, proceed to CTPA, and give thrombolysis if positive.
  • Consider thrombolysis, in addition, for evidence of right heart failure or pulmonary hypertension, even in absence of shock. Also for massive ileofemoral thrombosis.

Konstantinides S et al. Heparin plus alteplase compared with heparin alone in patients with submassive pulmonary embolism. NEJM 2002;347:1143-50. [Reference] (Editorial: Goldhaber SZ. NEJM 2002;347:1131-2).

Treatment of Pulmonary Embolus (PE)

  • Unfractionated heparin IV followed by warfarin (as for DVT).
  • LMW heparin should replace unfractionated, as is as effective and safe and is considerably simpler.
  • Some patients (as have a 30-day mortality risk ≤ 1.5%) may safely be managed as outpatients, providing have none of the high-risk features of age ≥ 70; any one of cancer/ heart failure/ chronic lung disease/ CRF/ cerebrovascular disease; pulse ≥ 110; SBP < 100 mmHg; altered mental status; SaO2 < 90%.

Quinlan D, McQuillan A, Eikelboom J. Low-molecular-weight heparin compared to intravenous unfractionated heparin for treatment of pulmonary embolism. A meta-analysis. Ann Intern Med 2004; 140:175-83. [Reference]

Aujesky D et al. A prediction rule to identify low-risk patients with pulmonary embolism. Arch. Intern. Med. 2006;166:169-75. (Editorial: Moores L. Arch. Intern. Med. 2006;166:147-8). [Reference]

Lee C, Hankey G et al. Venous thromboembolism: diagnosis and management of pulmonary embolism. MJA 2005;182:569-74. [Reference]

ACEP: Clinical policy: critical issues in the evaluation and management of adult patients presenting with suspected PE. Ann Emerg Med 2003; 41:257-70 [Reference].

British Thoracic Society guidelines for the management of suspected acute pulmonary embolism. Thorax 2003; 58: 470-484. [Reference]

Janata K. Managing pulmonary embolism. BMJ 2003; 326:1341-2. [Reference]

BodyMaps Human Atlas

bodymapsbeta 001 BodyMaps Human Atlas

Body maps is an online human atlas currently in beta testing phase at present. Body maps of adult male, adult female and child are available. Navigation is simple using the ’system tree’ menu on the left of the screen and it is possible to view the cardiovascular, muscular, lymphatic, nervous, respiratory and reproductive systems independently or in combination to enhance spatial orientation.

body maps 003 BodyMaps Human Atlas

I like the visuospatial overview; easy navigation keys; system markers and the hierarchical structure to help refine searching within the mapping system. Information is being added for each area of the map for pathological conditions and procedures associated with anatomical parts of the body. An expanding Wiki section is evolving and in combination with discussion groups this should be a very useful tool.

Check out the introductory video and give the beta trial a whirl – looks like fun!

body maps 004 BodyMaps Human Atlas

MEDNET 2008

13th World Congress on the Internet in Medicine

MEDNET 2008 is an international meeting aimed at bringing together researchers, developers and users involved in the application of the internet in medicine, starting either with a medical or technological background. Read more on the MedSchoolEvolution social site hosted by Ning.com

Saint-Petersburg

October 15-18, 2008

It is organised by SIM, the successor of the Society for the Internet in Medicine, an international scientific association devoted to promote the education of the public and of the medical community in the applications of the Internet and related technologies in the fields of the medical sciences, healthcare practice and management.

After hugely successful events held worldwide in Brighton (1996 and 1997), London (1998), Heidelberg (1999), Bruxelles (2000), Udine (2001), Amsterdam (2002), Geneva (2003), Buenos Aires (2004), Prague (2005), Toronto (2006) and Leipzig (2007), this year’s Congress will take place in Saint Petersburg (Russia), three days preceded and followed by tutorials and workshops centered on the Congress’ topics including

  • E-mobility and data-protection/security
  • Telemedicine, doctor to doctor, patient to doctor
  • Telemonitoring and self-management
  • Hospital management and the Internet
  • Semantic web
  • The Internet and the developing world
  • Ethical issues and legal aspects
  • Internet technologies and standards
  • Specialised Internet tools for medicine (search engines, filtering, etc)
  • Internet security and privacy
  • Evaluation and methodological issues in
  • E-health and telemedicine
  • E-learning, continuous medical education online
  • Patient portals
  • Personal health records online
  • Internet for life style support
  • Internet for chronically ill
  • Clinical trials and Internet
  • Usability and human factors on the Internet
  • Health information on the Internet
  • Business opportunities in e-health and telemedicine
  • Failures in e-health and telemedicine