Mac Sweeney’s Top Ten Critical Care Papers for 2013

Critical Care Reviews for ICN - TOP 10

I recently talked to Rob Mac Sweeney (@CritCareReviews) from Critical Care Reviews (reviewed here) about the ‘Top Ten’ randomised control trials in intensive care from 2013 for the SMACC podcast.

WARNING: Listening to this may cause your brain to blow a gasket! Do NOT attempt to listen to this at double speed!

If you think you can handle it, listen to the 45 minute podcast below or download via the direct link or iTunes (45.7 Mb mp3 file):

This podcast is best digested in conjunction with individual review of the papers discussed. Here are links for the articles:

Studies Reporting Beneficial Interventions

  1. Guérin et al. Prone Positioning in Severe Acute Respiratory Distress Syndrome (PROSEVA). New Engl J Med 2013;epublished May 20th [Article link] [CCC —Prone Position and Mechanical Ventilation]
  2. Mentzelopoulos et al. Vasopressin, Steroids, and Epinephrine and Neurologically Favorable Survival After In-Hospital Cardiac Arrest: A Randomized Clinical Trial. JAMA 2013;310(3):270  [Article link] [EMCrit Wee - Vasopressin, Steroids, and Epinephrine for Cardiac Arrest]
  3. Villanueva et al. Transfusion Strategies for Acute Upper Gastrointestinal Bleeding. N Engl J Med 2013;368:11-21  [Article link] [CCC — Transfusion Literature Summaries]

Studies Reporting Unsafe Interventions

  1. Heyland et al. A Randomized Trial of Glutamine and Antioxidants in Critically Ill Patients (REDOXS study). N Engl J Med 2013;368:1489-1497  [Article link] [CCC —Nutrition Literature Summaries]
  2. Ferguson et al. High-Frequency Oscillation in Early Acute Respiratory Distress Syndrome (OSCILLATE). New Engl J Med 2013;epublished January 22rd  [Article link] [CCC —High Frequency Oscillation Ventilation (HFOV)]
  3. Young et al. High-Frequency Oscillation for Acute Respiratory Distress Syndrome (OSCAR). New Engl J Med 2013;epublished January 22nd  [Article link]  [CCC —High Frequency Oscillation Ventilation (HFOV)]

Studies Reporting Neutral Interventions

  1. Young et al. Effect of Early vs Late Tracheostomy Placement on Survival in Patients Receiving Mechanical Ventilation: The TracMan Randomized Trial. JAMA 2013;309(20):2121  [Article link] [CCC —Timing of Tracheostomy]
  2. Reignier et al. Effect of Not Monitoring Residual Gastric Volume on Risk of Ventilator-Associated Pneumonia in Adults Receiving Mechanical Ventilation and Early Enteral Feeding:  A Randomized Controlled Trial. JAMA 2013;309(3):249  [Article link] [CCC — Gastric Residual Volume]
  3. Kerlin et al. A Randomized Trial of Nighttime Physician Staffing in an Intensive Care Unit. New Engl J Med 2013;epublished May 20th  [Article link]
  4. Doig et al. Early Parenteral Nutrition in Critically Ill Patients With Short-term Relative Contraindications to Early Enteral Nutrition: A Randomized Controlled Trial. JAMA 2013;epublished May 20th  [Article link] [CCC —Nutrition Literature Summaries]

Bonus study!

  1. Prasad. A Decade of Reversal: An Analysis of 146 Contradicted Medical Practices. Mayo Clinic Proceedings 2013;epublished July 22nd  [Article link] [CCC —Medical Reversal]

If you’re in the UK or Europe make sure you don’t miss Rob’s upcoming 2014 Critical Care Reviews meeting in Belfast:

“If you like following the critical care literature on Critical Care Reviews, then you’ll love the 2nd Critical Care Reviews Meeting on Friday January 24th, Belfast, Northern Ireland. The top local intensivists discuss the major research of 2013; medical specialists explore new developments in their field, while global giants Alistair Nichol (Dublin), Mervyn Singer (London) and John Marshall (Toronto) provide thought provoking analyses questioning current critical care practices. It’s a packed meeting, running from early morning to late night, full of entertaining debate and lively deliberation. If you can’t make it, a live twitter stream will be on #CCRMeeting, with vodcasts of the presentations available shortly after the meeting on Critical Care Reviews.”

Both Rob and I will be at smaccGOLD, see you there!

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  1. says

    Thanks Chris. If I pass this exam you (and the rest of LITFL) are getting a case of (nice) beer, in addition to the bouquet of flowers I’m getting the editors of CEACCP.