HB-O2 dissociation curve

Physiology Phile 002

Welcome to the Physiology Philes series, part of the basic science in clinical context project on LITFL.

This video takes us through the haemoglobin – oxygen dissociation curve.

This is a sigmoid curve which relates the partial pressure of oxygen dissolved in the blood to the percentage saturation of haemoglobin.  It allow us to understand how haemoglobin hungrily binds to oxygen in the high partial pressures within the alveoli, but happily gives it up where it’s needed most, at the tissue level.

The key is understanding how heamoglobin works,  and that there is cooperative binding – meaning the more oxygen that attaches to Hb, the more  molecules it binds, and the opposite happens when O2 starts to move away from the Hb molecule. It explains why there is a ‘slippery slope’ once the Hb saturation falls lower than 92%. The video also explains the numbers you need to know to draw the curve, and then looks at some of the physiological and pathological situations that shift the curve.

https://gmep.org/media/11807

References:

  • Medical Physiology 2nd edition Boron and Boulpaep
  • The Physiology Coloring Book Kapit, Macey, Meisami
  • Vent World
  • CCM Tutorials

 

 

 

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    • says

      Thanks -- soon there will be lots of not only Physiology, but all the Basic Sciences posts coming online -- hopefully good for practice also , not just exams :-). Andy’s clinical anatomy posts are quite brilliant.

  1. jacinta says

    Hi,

    What soft ware do I need to see the HB0 dissasociation curve video? There is a blank space between the boxed text and references on my screen.

    Cheers
    jacinta

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