Right Ventricular Infarction

Clinical Significance

  • Right ventricular infarction complicates up to 40% of inferior STEMIs. Isolated RV infarction is extremely uncommon.
  • Patients with RV infarction are very preload sensitive (due to poor RV contractility) and can develop severe hypotension in response to nitrates or other preload-reducing agents.
  • Hypotension in right ventricular infarction is treated with fluid loading, and nitrates are contraindicated.

The ECG changes of RV infarction are subtle and easily missed!

How to spot right ventricular infarction

The first step to spotting RV infarction is to suspect it… in all patients with inferior STEMI!

In patients presenting with inferior STEMI, right ventricular infarction is suggested by the presence of:

  • ST elevation in V1 – the only standard ECG lead that looks directly at the right ventricle.
  • ST elevation in lead III > lead II  – because lead III is more “rightward facing” than lead II and hence more sensitive to the injury current produced by the right ventricle.

Other useful tips for spotting right ventricular MI (as described by Amal Mattu and William Brady in ECGs for the Emergency Physician):

  • ST elevation in V1 > V2.
  • ST elevation in V1 + ST depression in V2 (= highly specific for RV MI).
  • Isoelectric ST segment in V1 with marked ST depression in V2.

Right ventricular infarction is confirmed by the presence of ST elevation in the right-sided leads (V3R-V6R).

Right-sided leads

There are several different approaches to recording a right-sided ECG:

  • A complete set of right-sided leads is obtained by placing leads V1-6 in a mirror-image position on the right side of the chest (see diagram, below).
  • It may be simpler to leave V1 and V2 in their usual positions and just transfer leads V3-6 to the right side of the chest (i.e. V3R to V6R).
  • The most useful lead is V4R, which is obtained by placing the V4 electrode in the 5th right intercostal space in the midclavicular line.
  • ST elevation in V4R has a sensitivity of 88%, specificity of 78% and diagnostic accuracy of 83% in the diagnosis of RV MI.

Reproduced from Morris and Brady, 2002. Click image for link to original reference.

NB. ST elevation in the right-sided leads is a transient phenomenon, lasting less than 10 hours in 50% of patients with RV infarction.

Example ECGs

Example 1a

Inferior STEMI. Right ventricular infarction is suggested by:

  • ST elevation in V1
  • ST elevation in lead III > lead II


Example 1b

Repeat ECG of the same patient with V4R electrode position:

  • There is ST elevation in V4R consistent with RV infarction


Example 2

Another example of right ventricular MI:

  • There is an inferior STEMI with ST elevation in lead III > lead II.
  • There is subtle ST elevation in V1 with ST depression in V2.
  • There is ST elevation in V4R.


Example 3

This ECG shows a full set of right-sided leads (V3R-V6R), with V1 and V2 in their original positions. RV infarction is diagnosed based on the following findings:

  • There is an inferior STEMI with ST elevation in lead III > lead II.
  • V1 is isoelectric while V2 is significantly depressed.
  • There is ST elevation throughout the right-sided leads V3R-V6R.


Example 4a

Inferior STEMI ?RVTry this one yourself.


  • Inferior STEMI with STE in III > II
  • Reciprocal ST depression in aVL and V1
  • Isoelectric / slightly elevated ST segment in V1 with ST depression in V2-3
  • These findings are consistent with inferior STEMI due to RCA occlusion, plus likely associated RV infarction.


Example 4b

Same patient, 9 minutes later.

RV MI confirmed

  • Rapid evolution of inferior STEMI with dynamic increase in height of ST segments – this patient needs urgent PCI!
  • V4R shows loss of R-wave height, significant ST elevation (> 0.5mm; ST segment > R wave) and hyperacute T wave (very large T wave given amplitude of QRS complex) – this confirms the diagnosis of RV MI.
  • Development of Wenckebach 2nd degree AV block indicates AV node ischaemia or a Bezold-Jarisch reflex (increased vagal tone often seen with inferior MI).

Related Topics

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  1. Ian says

    Hi there, just a note from my tutor

    right ventricular infarct as suggested by deep ST depression in lead 1 and avL (>3mm added together), ST elevation of lead 3>lead2….
    RV infarct accompanies inf infarct in about 50% of the time….
    You could do a right sided ECG to confirm it… most prominent change in vR4…


  1. […] contiguous leads, either:Septal (V1-2)Anterior (V3-4)Lateral (I + aVL, V5-6)Inferior (II, III, aVF)Right ventricular (V1, V4R)Posterior (V7-9)There is usually reciprocal ST depression in the electrically opposite leads.Follow […]