Beta-blocker & Calcium-channel blocker toxicity

Relevant Agents

• Beta-blockers: Atenolol, metoprolol, propranolol, sotalol.
• Cardioselective calcium-channel blockers: Verapamil and diltiazem.

Effects on the ECG

• Sinus bradycardia.
• 1st, 2nd and 3rd degree AV block.
• Junctional bradycardia.
• Ventricular bradycardia.

A prolonged PR interval is an early sign of beta-blocker or calcium-channel blocker toxicity – even in the absence of significant bradycardia.

Specific Agents

Two of the beta-blockers have additional important toxic effects:

• Propranolol behaves more like a tricyclic antidepressant in overdose than a beta-blocker, due to its blockade of myocardial and CNS fast sodium channels. Propranolol toxicity is associated with QRS widening and a positive R’ wave in aVR (signs of sodium channel blockade), which portend the onset of coma, seizures, hypotension and ventricular arrhythmias.
• Sotalol blocks myocardial potassium channels, causing QT prolongation and Torsades de Pointes in overdose.

ECG Examples

Example  1

Sinus bradycardia with 1st-degree AV block:

• Heart rate 45 bpm.
• PR interval 240 ms.

This type of ECG pattern is commonly seen in the early stages of beta-blocker / calcium-channel blocker poisoning.

 

Example 2

Slow junctional rhythm:

• Regular  rhythm at 30 bpm.
• Narrow QRS complexes
• No visible P waves

 

Example 3

Complete heart block:

• Sinus rhythm – P waves occur at a rate of around 90 bpm.
• 3rd degree AV block – there is no relationship between the P waves and QRS complexes.
• Slow escape rhythm (30 bpm) with a RBBB morphology – this could be either a ventricular escape rhythm or a slow junctional rhythm with RBBB.

 

Example 4 - Sotalol poisoning

This ECG demonstrates the key features of sotalol overdose:

• Sinus bradycardia.
• Very long QT interval (~600ms).

NB. This patient is at significant risk of Torsades de Pointes.

 

Example 5 – Propranolol poisoning

This ECG demonstrates some of the key features of propranolol overdose:

• 1st degree AV block.
• Signs of sodium-channel blockade: QRS broadening (> 100 ms) and positive R’ wave in aVR (> 3mm).

NB. Normally the heart rate would be slower than this in a propranolol overdose (this is actually an ECG of flecainide poisoning — another sodium-channel blocking agent).

 

Related Topics

• Tricyclic antidepressant overdose (sodium-channel blocker toxicity)
• Digoxin toxicity
• Carbamazepine toxicity
• Quetiapine toxicity

Further Reading

References

• Murray L, Daly F, Little M, Cadogan M. Toxicology Handbook (second edition). Elsevier, 2011.