Hyperkalaemia

Background

  • Potassium is vital for regulating the normal electrical activity of the heart.
  • Increased extracellular potassium reduces myocardial excitability, with depression of both pacemaking and conducting tissues.
  • Progressively worsening hyperkalaemia leads to suppression of impulse generation by the SA node and reduced conduction by the AV node and His-Purkinje system, resulting in bradycardia and conduction blocks and ultimately cardiac arrest.

Definitions

  • Hyperkalaemia is defined as a potassium level > 5.5 mEq/L
  • Moderate hyperkalaemia is a serum potassium > 6.0 mEq/L
  • Severe hyperkalaemia is a serum potassium > 7.0 mE/L

Effects of hyperkalaemia on the ECG

Serum potassium > 5.5 mEq/L is associated with repolarization abnormalities:

  • Peaked T waves (usually the earliest sign of hyperkalaemia)

Serum potassium > 6.5 mEq/L is associated with progressive paralysis of the atria:

  • P wave widens and flattens
  • PR segment lengthens
  • P waves eventually disappear

Serum potassium > 7.0  mEq/L is associated with conduction abnormalities and bradycardia:

  • Prolonged QRS interval with bizarre QRS morphology
  • High-grade AV block with slow junctional and ventricular escape rhythms
  • Any kind of conduction block (bundle branch blocks, fascicular blocks)
  • Sinus bradycardia or slow AF
  • Development of a sine wave appearance (a pre-terminal rhythm)

Serum potassium level of > 9.0 mEq/L causes cardiac arrest due to:

  • Asystole
  • Ventricular fibrillation
  • PEA with bizarre, wide complex rhythm

(Warning! In individual patients, the serum potassium level may not correlate closely with the ECG changes. Patients with relatively normal ECGs may still experience sudden hyperkalaemic cardiac arrest.)

Peaked T waves

Prolonged PR segment

Loss of P waves

Bradycardia

Sine wave

Handy Tips

  • Suspect hyperkalaemia in any patient with a new bradyarrhythmia or AV block, especially patients with renal failure, on haemodialysis or taking any combination of ACE inhibitors, potassium-sparing diuretics and potassium supplements.
  • For an excellent review of the management of hyperkalaemia, check out this podcast by Scott Weingart.

ECG Examples

Example 1

This ECG displays many of the features of hyperkalaemia:

  • Prolonged PR interval.
  • Broad, bizarre QRS complexes — these merge with both the preceding P wave and subsequent T wave.
  • Peaked T waves.

This patient had a serum K+ of 9.2. 

 

Example 2

Hyperkalaemia

  • Tall, symmetrically peaked T waves.

This patient had a serum K+ of 7.0.

 

Example 3

Hyperkalaemia

  • Long PR segment.
  • Wide, bizarre QRS.

 

Example 4

Hyperkalaemia:

  • Slow junctional rhythm.
  • Intraventricular conduction delay.
  • Peaked T waves.

 

Example 5

Hyperkalaemia:

  • Broad complex rhythm with atypical LBBB morphology.
  • Left axis deviation.
  • Absent P waves.

 

Example 6

Hyperkalaemia:

  • Sine wave appearance with severe hyperkalaemia (K+ 9.9 mEq/L).

 

Example 7

Hyperkalaemia:

  • Huge peaked T waves.
  • Sine wave appearance.

This patient had severe hyperkalaemia (K+ 9.0 mEq/L) secondary to rhabdomyolysis.

 

Related Topics

Further Reading

Author Credits

References

  • Mattu A, Brady W. ECGs for the Emergency Physician 2, BMJ Books 2008.
  • Cameron P, Jelinek G, Kelly AM, Murray L, Brown AFT. Textbook of Adult Emergency Medicine. Elsevier 2009
  • Ganong, WF. Review of Medical Physiology (22nd edition). Lange / McGraw-Hill 2005.
  • Hampton, JR. The ECG in Practice (5th edition), Churchill Livingstone 2008.
  • Phibbs BP. Advanced ECG: Boards and Beyond (second edition). Elsevier 2006.
  • Slovis C, Jenkins R. ABC of clinical electrocardiography: Conditions not primarily affecting the heart. BMJ. 2002 Jun 1;324(7349):1320-3. Review. PMID: 12039829. Full text.
  • Wagner, GS. Marriott’s Practical Electrocardiography (11th edition), Lippincott Williams & Wilkins 2007.
Print Friendly