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Sodium Bicarbonate

Hyperosmolar sodium bicarbonate solutions are widely used in clinical toxicology both as an antidote to drugs that impair fast sodium channel function and as an alkalinising agent to manipulate drug distribution and excretion.

References

  • Bradberry SM, Thanacoody HK, Watt BE et al.  Management of the cardiovascular complications of tricyclic antidepressant poisoning: role of sodium bicarbonate.  Toxicological Reviews 2005; 24(3):195-204.
  • Proudfoot AT, Krenzelok EP, Brent J et al.  Does urine alkalinization increase salicylate elimination? If so, why?  Toxicological Reviews 2003; 22(3):129-136.

Toxicology Handbook

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About Mike Cadogan

Emergency physician with a passion for medical informatics and medical education. Co-founder of HealthEngine, iMeducate, and the GMEP. He writes more eclectically on the web as @sandnsurf | + Mike Cadogan | Contact