Salicylates

Acute intoxication presents with classical symptoms of vomiting, tinnitus, hyperventilation, respiratory alkalosis and metabolic acidosis. Severe toxicity may result in coma and seizures. Chronic intoxication presents with non-specific clinical features and the diagnosis is frequently missed. Morbidity and mortality are greater in chronic intoxication. Urinary alkalinisation and haemodialysis are highly effective methods at enhancing elimination.

References

• Davis JE.  Are one or two dangerous?  Methyl salicylate exposure in toddlers.  Journal of Emergency Medicine 2007; 32(1):63-69.
• O’Malley GF.  Management of the salicylate poisoned patient.  Emergency Medicine Clinical of North America 2007: 25(2): 333-336.
• Pearlman BL, Gambhir R.  Salicylate intoxication: A clinical review.  Postgraduate Medicine 2009; 121(4): 162-168.