Quetiapine is a second-generation atypical antipsychotic agent. Deliberate self-poisoning is associated with sedation, delirium, coma, tachycardia and hypotension. It is currently a leading cause of toxic coma requiring intensive care admission. Thorough supportive care ensures a good outcome.
References
- Balit CR, Isbister GK, Hackett LP. Quetiapine: A case series. Annals of Emergency Medicine 2003; 42: 751-758.
- Burns MJ. The pharmacology and toxicology of atypical antipsychotic agents. Journal of Toxicology-Clinical Toxicology 2001; 39(1): 1-14.
- Hawkins DJ, Unwin P. Paradoxical and severe hypotension in response to adrenaline infusion in massive quetiapine overdose. Critical Care and Resuscitation 2008; 10(4):320-322.
- Isbister GK, Balit CR, Kilham HA. Antipsychotic poisoning in young children: A systematic review. Drug Safety 2005; 26(11):1029-1044.
- Ngo A, Ciranni M, Olson KR. Acute quetiapine overdose in adults: A 5-year retrospective case series Annals of Emergency Medicine 2008; 52:541-547.
- Tan HH, Hoppe J, Heard K. A systematic review of cardiovascular effects after atypical antipsychotic medication overdose. American Journal of Emergency Medicine 2009; 27:607-616.
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