Opioid Dependence and Withdrawal

Opioid withdrawal syndrome is the physiological response that develops when there is abrupt cessation or rapid reduction in opioid dose in a dependent individual, or when that individual is administered an opioid antagonist or partial agonist.

References

  • Kosten TR, O’Connor PG. Management of drug and alcohol withdrawal. New England Journal of Medicine 2003; 348:1786-1795.
  • Olmedo R, Hoffman RS. Withdrawal syndromes. Emergency Medicine Clinics of North America 2000; 18(2):273-288.
  • Tetrault JM, O’Connor PG.  Substance abuse and withdrawal in the critical care setting.  Critical Care Clinics 2008; 24:767-788.
  • Webster IW (Chair of the Detoxification Guidelines Project Steering Committee). New South Wales Detoxification Guidelines. NSW health Department 1999. State Health publication Number (DTPU) 990049, May 1999.

Toxicology Handbook

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About Mike Cadogan

Emergency physician with a passion for medical informatics and medical education. Co-founder of HealthEngine, iMeducate, and the GMEP. He writes more eclectically on the web as @sandnsurf | + Mike Cadogan | Contact