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Olanzapine

Deliberate self-poisoning with this second-generation atypical antipsychotic agent is associated with sedation, delirium and coma in ascending doses. Thorough supportive care ensures a good outcome.

References

  • Burns MJ. The pharmacology and toxicology of atypical antipsychotic agents. Journal of Toxicology-Clinical Toxicology 2001;39(1):1-14.
  • Palenzona S, Meier PJ, Kupferschmidt H, Rauber-Luethy C. Clinical picture of olanzapine poisoning with special reference to fluctuating mental status. Journal of Toxicology-Clinical Toxicology 2004;42(1):27-32.
  • Isbister GK, Balit CR, Kilham HA. Antipsychotic poisoning in young children: A systematic review. Drug Safety 2005;26(11):1029-1044

Toxicology Handbook

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About Mike Cadogan

Emergency physician with a passion for medical informatics and medical education. Co-founder of HealthEngine, iMeducate, and the GMEP. He writes more eclectically on the web as @sandnsurf | + Mike Cadogan | Contact