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Newer Anticonvulsant Agents

The newer anticonvulsants are generally much less toxic in overdose than the older agents

References

  • Fischer JH, Barr AN, Rogers SL, Fischer PA, Trudeau VL. Lack of serious toxicity following gabapentin overdose.  Neurology 1994; 44(5):982-9833.
  • Klein-Schwartz W, Shepherd JG, Gorman S et al. Characterization of gabapentin overdose using a poison center case series. Journal of Toxicology-Clinical Toxicology 2003; 41(1):11-15.
  • Lofton AL, Klein-Schwartz W.  Evaluation of lamotrigine toxicity reported to poison centers.  Annals of Pharmaotherapy 2004; 38:1811-1815.
  • Traub JS, Howland MA, Hoffman RS et al. Acute Topiramate Toxicity. Journal of Toxicology-ClinicalToxicology 2003; 41(7):987-990.
  • Wade JF, Dang CV, Nelson L et al.  Emergent complications of the newer anticonvulsants.  Journal of Emergency Medicine 2008; Aug 30 [Epub ahead of press].
  • Wisniewski M, Lukasek-Glebocka  M, Anand JS. Acute topiramate overdose – clinical manifestations. Clinical Toxicology 2009; 47:317-320.

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About Mike Cadogan

Emergency physician with a passion for medical informatics and medical education. Co-founder of HealthEngine, iMeducate, and the GMEP. He writes more eclectically on the web as @sandnsurf | + Mike Cadogan | Contact