Methotrexate

The toxic effects of this antimetabolite are employed therapeutically in the treatment of a variety of neoplastic conditions, psoriasis and rheumatoid arthritis. Toxicity is not described following acute overdose but is severe toxicity occurs following repeated supratherapeutic dosing. Folinic acid (leucovorin) is used in selected cases

References

Balit C, Daly FFS, Little M et al. Acute methotrexate overdose (abstract). Clinical Toxicology 2006; 44(3).
Lovecchio F, Katz K, Watts D, et al. Four-year experience with methotrexate exposures. Journal of Medical Toxicology 2008; 4(3):149-150.

About Mike Cadogan

Emergency physician with a passion for medical informatics and medical education. Co-founder of HealthEngine, iMeducate, and the GMEP. He writes more eclectically on the web as @sandnsurf | + Mike Cadogan | Contact