Intravenous lipid emulsion

Intravenous lipid emulsion (IVLE) is a sterile emulsion of soyabean oil in water, used in parenteral nutrition. It is a novel antidote which requires further study but may have a role to play in the resuscitation of patients with refractory cardiac arrest induced by local anaesthetics or other lipophilic agents.

References

• The Association of Anaesthetists of Great Britain and Ireland.  Guidelines for the management of severe local anaesthetic toxicity. August 2007; Available: http://www.aagbi.org.
• Weinberg G. Lipid rescue resuscitation from local anaesthetic cardiac toxicity.  Toxicological Reviews 2006; 25(3):139-145.
• Turner-Lawrence DE, Kerns W. Intravenous fat emulsion: a potential novel antidote.  Journal of Medical Toxicology 2008; 4(2):109-114.
• Felice KL, Schumann HM. Intravenous lipid emulsion for local anaesthetic toxicity: a review of the literature. Journal of Medical Toxicology 2008; 4(3):184-191.