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Insulin (high-dose)

High-dose insulin therapy is a novel therapeutic intervention that produces a significant inotropic response in severe calcium channel blocker (CCB) overdose.

References

  • Yuan TH, Kerns WP, Tomaszewski CA et al.  Insulin-glucose as adjunctive therapy for severe calcium channel antagonist poisoning. Journal of Toxicology – Clinical Toxicology 1999; 37(4):463-474.
  • Lheureux PE, Zahir S, Gris M et al.  Bench-to-bedside review: Hyperinsulinaemia/euglycaemia therapy in the management of overdose of calcium-channel blockers. Critical Care 2006; 10:212.
  • Megarbane B, Karyo S, Baud FJ.  The role of insulin and glucose (hyperinsulinaemia/euglycaemia) therapy in acute calcium channel antagonist and beta-blocker poisoning.  Toxicological Reviews 2004; 23(4):215-222.

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About Mike Cadogan

Emergency physician with a passion for medical informatics and medical education. Co-founder of HealthEngine, iMeducate, and the GMEP. He writes more eclectically on the web as @sandnsurf | + Mike Cadogan | Contact