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Hydroxocobalamin

Hydroxocobalamin is a vitamin B12 (cyanocobalamin) precursor. In high doses, it is an effective chelator of cyanide.

References

  • Borron SW, Baud FJ, Megarbane B et al.  Hydroxocobalamin for severe acute cyanide poisoning by ingestion or inhalation.  American Journal of Emergency Medicine 2007; 25:551-518.
  • Hall AH, Dart R, Bogdan G. Sodium thiosulfate or hydroxocobalamin for empiric treatment of cyanide poisoning? Annals of Emergency Medicine 2007; 49:806-813.
  • IPCS/CEC evaluation of antidotes series. Volume 2. Antidotes for poisoning by cyanide.  Meredith TJ, Jacobsen D, Haines JA and Berger J-C.  Cambridge University Press 1993.

Toxicology Handbook

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About Mike Cadogan

Emergency physician with a passion for medical informatics and medical education. Co-founder of HealthEngine, iMeducate, and the GMEP. He writes more eclectically on the web as @sandnsurf | + Mike Cadogan | Contact