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Fomepizole

Alcohol dehydrogenase inhibitor used in management of methanol and ethylene glycol poisoning. It is not currently available in either Australia or New Zealand.

References

  • Barceloux DG, Krenzelok EK, Olson K et al. American Academy of Clinical Toxicology Practice Guidelines on the Treatment of Ethylene Glycol Poisoning. Journal of Toxicology – Clinical Toxicology 1999; 37:537-560.
  • Brent J, McMartin K, Phillips SP et al.  Fomepizole for the treatment of ethylene glycol poisoning.  New England Journal of Medicine 1999; 340:832-838.
  • Brent J, McMartin K, Phillips SP et al.  Fomepizole for the treatment of methanol poisoning.  New England Journal of Medicine 2001; 344:424-429.
  • Brent J. Fomepizole for ethylene glycol and methanol poisoning. New England Journal of Medicine 2009; 360:2216-2223.
  • Lepik KJ, Levy AR, Sobolev BG et al.  Adverse drug events associated with the antidotes for methanol and ethylene glycol poisoning: a comparison of ethanol and fomepizole. Annals of Emergency Medicine 2009; 53:439-450.

Toxicology Handbook

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About Mike Cadogan

Emergency physician with a passion for medical informatics and medical education. Co-founder of HealthEngine, iMeducate, and the GMEP. He writes more eclectically on the web as @sandnsurf | + Mike Cadogan | Contact