This combination drug causes delayed onset of opioid and anticholinergic effects when ingested by children, even in small amounts.
References
- McCarron MM, Chalhower KR, Thompson GA. Dipheoxylate-atropine (Lomotil) overdose in children: an update (report of 8 cases and review of the literature). Pediatrics 1991; 87(5):694-700.
- Thomas TJ, Pauze D, Love JN. Are one or two dangerous? – Diphenoxylate-atropine exposure in toddlers. The Journal of Emergency Medicine 2008; 34(1):71-75.































