These antibody fragments promptly and safely reverse the toxicity of digoxin and other cardiac glycosides
References
- Antman EM, Wenger TL, Butler VP et al. Treatment of 150 cases of life-threatening digitalis intoxication with digoxin-specific Fab antibody fragments: final report of a multicenter study. Circulation 1990; 81(6):1744-1752.
- Bateman DN. Digoxin-specific antibody fragments: how much and when? Toxicological Reviews 2004; 23(3):135-143.
- Di Domenico R, Walton S, Sanoski CA et al. Analysis of the use of digoxin Fab for the treatment of non life threatening digoxin toxicity. Journal of Cardiovascular Pharmacology and Therapeutics 2000; 5(2):77-85.
- Eddleston M, Rajapakse S, Rajakanthan et al. Anti-digoxin Fab fragments in cardiotoxicity induced by ingestion of yellow oleander: a randomised controlled trial. Lancet 2000; 355(9208):967-972.
- Lapostelle F, Borron SW, Verdier C et al. Digoxin-specifc Fab fragments in single first-line therapy in digitalis poisoning. Critical Care Medicine 2008; 36:3014-3018.
- Woolf AD, Wenger T, Smith TW et al. The use of digoxin-specific Fab fragments for severe digitalis intoxication in children. New England Journal of Medicine 1992; 326:1739-1744.
About Mike Cadogan
