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Clozapine

Deliberate self-poisoning with this atypical antipsychotic agent is unusual because its use is restricted and highly supervised. Care is supportive.

References

  • Burns MJ. The pharmacology and toxicology of atypical antipsychotic agents. Clinical Toxicology 2001: 39(1);1-14.
  • Isbister GK, Balit CR, Kilham HA. Antipsychotic poisoning in young children: A systematic review. Drug Safety 2005; 26(11):1029-1044.
  • Trenton A, Currier G, Zwemer F. Fatalities associated with therapeutic use and overdose of atypical antipsychotics. CNS Drugs 2003; 17(5):307-324.
  • Reith D, Monteleone JP, Whyte IM et al.  Features and toxicokinetics of clozapine in overdose. Therapeutic Drug Monitoring. 1998; 20(1):92-97.

Toxicology Handbook

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About Mike Cadogan

Emergency physician with a passion for medical informatics and medical education. Co-founder of HealthEngine, iMeducate, and the GMEP. He writes more eclectically on the web as @sandnsurf | + Mike Cadogan | Contact