Carbon Monoxide

Carbon monoxide is a common cause of poisoning death. Acute effects are secondary to tissue hypoxia. Delayed neurological sequelae are secondary to an incompletely understood cascade of endovascular oxidative injury and inflammation.

Resources

• Smoking is Deadly (Tox Conundrum 38)

References

• Buckley NA, Isbister GK, Stokes B et al. Hyperbaric Oxygen for Carbon Monoxide Poisoning: A Systematic Review and Critical Analysis of the Evidence. Toxicological Reviews 2005: 24(2):75-92.
• Juurlink DN, Buckley NA, Stanbrook MB et al. Hyperbaric oxygen for carbon monoxide poisoning. The Cochrane Database of Systematic Reviews 2005, Issue 1. Art. No.: CD002041.pub2. DOI: 10.1002/14651858.CD002041.pub2
• Scheinkestel CD, Bailey M, Myles PS et al. Hyperbaric or normobaric oxygen for acute carbon
• monoxide posioning: a randomised controlled clinical trial. Medical Journal of Australia 1999; 170:203–210.
• Weaver LK, Hopkins RO, Chan KJ et al.  Hyperbaric oxygen for acute carbon monoxide poisoning. New England Journal of Medicine 2002; 347(14):1057–1067.