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Carbamazepine

Carbamazepine is an anticonvulsant. Deliberate self-poisoning results in predictable dose-dependent central nervous and anticholinergic effects.  Management is supportive with the selected use of enhanced elimination techniques.

References

  • Spiller HA. Management of carbamazepine overdose. Pediatric Emergency Care 2001; 17(6):452-456.
  • Hojer J, Malmlund HO, Berg A. Clinical features in 28 consecutive cases of laboratory confirmed massive poisoning with carbamazepine alone. Journal of Toxicology-Clinical Toxicology 1993; 31:449-458
  • Apfelbaum JD, Carabati EM, & Kerns WP II. Cardiovascular effects of carbamazepine toxicity.  Annals of Emergency Medicine 1995; 25: 631-635.
  • Tapolyai M et al. Hemodialysis is as effective as hemoperfusion for drug removal in carbamazepine poisoning.  Nephron 2002; 90(2): 213-215
  • Jones AL, Proudfoot AT. Features and management of poisoning with modern drugs used to treat epilepsy. Quartery Journal of Medicine 1998; 91:325-332

Toxicology Handbook

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About Mike Cadogan

Emergency physician with a passion for medical informatics and medical education. Co-founder of HealthEngine, iMeducate, and the GMEP. He writes more eclectically on the web as @sandnsurf | + Mike Cadogan | Contact