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Bupropion

This antidepressant agent is now used to suppress nicotine craving and is only available as an extended-release preparation.   There is high risk of seizures following an overdose of any amount and potential for life-threatening cardiotoxicity occurs with very high doses. Supportive care and adequate benzodiazepine sedation usually ensure a good outcome.

References

  • Balit CR, Lynch CN & Isbister GK.  Bupropion poisoning a case series. Medical Journal of Australia 2003; 178:61-63.
  • Morazin F, Lumbroso A, Harry P.  Cardiogenic shock and status epilepticus after massive bupropion overdose.  Clinical Toxicology 2007; 45(7):794-797.
  • Shepherd G, Veliz LI, Keys DC.  Intentional Bupropion Overdoses.  The Journal of Emergency Medicine 2004; 27(2):147-151.

Toxicology Handbook

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About Mike Cadogan

Emergency physician with a passion for medical informatics and medical education. Co-founder of HealthEngine, iMeducate, and the GMEP. He writes more eclectically on the web as @sandnsurf | + Mike Cadogan | Contact