LITFL » Books » Toxicology Handbook » Benzodiazepines

Benzodiazepines

Benzodiazepines are involved in up to one third of deliberate self-poisonings. An excellent prognosis is expected with supportive care of CNS depression. Flumazenil is a useful diagnostic and therapeutic tool in carefully selected cases.

References

  • Buckley NA, Dawson AH, Whyte IM: Relative toxicity of benzodiazepines in overdose. British Medical Journal 1995; 310:219-221.
  • Garnier R, Guerault E, Muzard D, et al. Acute zolpidem poisoning – analysis of 344 cases.  Journal of Toxicology-Clinical Toxicology 1994; 32(4):391-394.
  • Isbister GK, O’Regan L, Sibbritt D et al. Alprazolam is relatively more toxic than other benzodiazepines in overdose. British Journal of Clinical Pharmacology 2004; 58(1): 88-95.

Toxicology Handbook

Print Friendly
About Mike Cadogan

Emergency physician with a passion for medical informatics and medical education. Co-founder of HealthEngine, iMeducate, and the GMEP. He writes more eclectically on the web as @sandnsurf | + Mike Cadogan | Contact