Overdose is characterised by dose-dependent sedation and anticholinergic effects. Cardiovascular toxicity is associated with massive ingestions.
References
- Clark RF, Vance MV. Massive diphenhydramine poisoning resulting in a wide-complex tachycardia: successful treatment with sodium bicarbonate. Annals of Emergency Medicine 1992; 21:318-321.
- Burns MJ, Linden CH, Graudins A, et al. A comparison of physostigmine and benzodiazepines for the treatment of anticholinergic poisoning. Annals of Emergency Medicine 2000; 35(4):374-381.
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