Antihistamines (sedating)

Overdose is characterised by dose-dependent sedation and anticholinergic effects. Cardiovascular toxicity is associated with massive ingestions.


  • Clark RF, Vance MV. Massive diphenhydramine poisoning resulting in a wide-complex tachycardia: successful treatment with sodium bicarbonate. Annals of Emergency Medicine 1992; 21:318-321.
  • Burns MJ, Linden CH, Graudins A, et al. A comparison of physostigmine and benzodiazepines for the treatment of anticholinergic poisoning.  Annals of Emergency Medicine 2000; 35(4):374-381.

Toxicology Handbook

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