Antihistamines (non-sedating)

The non-sedating antihistamines produce mild CNS depression in overdose. They are notable for their association with QT prolongation in therapeutic and supratherapeutic doses although this association is less marked with the newer currently available agents


  • Hoffman RJ, de Souza I, Stetz JE. Prolonged QT segment and syncope with loratadine use (abstract). J Toxicology-Clinical Toxicology 2001; 39:505.
  • Pinto YM, Van Gelder IC, Heeringa M et al. QT lengthening and life-threatening arrhythmias associated with fexofenadine. Lancet 1999; 353:980.

Toxicology Handbook

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