Overdose with angiotensin converting enzyme (ACE) inhibitors is relatively benign. The principal toxic effect is mild to moderate hypotension usually responsive to fluid therapy alone.
References
- Balit CR, Gilmore SP, Isbister GK. Unintentional paediatric ingestions of angiotensin converting enzyme inhibitors and angiotensin II receptor antagonists. Journal of Paediatrics and Child Health 2007 ;43(10):686-668.
- Christie GA, Lucas C, Bateman DN et al. Redefining the ACE-inhibitor dose-response relationship: substantial blood pressure lowering after massive doses. European Journal of Clinical Pharmacology 2006; 62(12):989-993.
- Varughese A, Taylor AA, Nelson EB. Consequences of angiotensin-converting enzyme inhibitor overdose. American Journal of Hypertension 1989; 2:355-357.
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