Tranexamic acid

Tranexamic acid

[1 vial $12.81]

ADMINISTRATION ROUTES:

• IV

ALTERNATIVE NAMES:

• Cyklokapron

ICU INDICATIONS:

1. Bleeding post-cardiac surgery or other bleeding due to fibrinolysis
2. Major trauma with significant bleeding risk

PRESENTATION AND ADMINISTRATION:

• IV:500mg in 5ml (solution)
  Preferred method of administration is via direct IV injection at a rate of 1ml (100mg) per minute
  Can be administered by intermittent infusion by adding dose to a suitable volume of compatible IV fluid and infusing at a rate of 100mg/min
  Compatible with the following IV fluids: 0.9% sodium chloride 5% or 10% glucose Glucose and Sodium Chloride Store at room temperature. Use dilutions in IV fluid within 24 hours of preparation

DOSAGE:

• IV: 10-25 mg/kg 8 hourly For major trauma: 1 gm over 10 mins then 1 gm over 8 hrs by infusion

DOSAGE IN RENAL FAILURE AND RENAL REPLACEMENT THERAPY:

• Dose in renal impairment [GFR (ml/min)]:
  <10: 5mg/kg 24 hourly
  10-20: 5mg/kg 24 hourly
  >20-50: 10mg/kg 24 hourly
• Dose in renal replacement therapy:
  CAPD: 10mg/kg 12 hourly
  HD: 10mg/kg 24 hourly
  CVVHDF: 5mg/kg 24 hourly

DOSAGE IN PAEDIATRICS:

• IV: 10-20mg/kg 8 hourly

CLINICAL PHARMACOLOGY:

• Tranexamic acid is an antifibrinolytic.

CONTRAINDICATIONS:

1. previous DVT or PE
2. hypersensitivity to tranexamic acid

WARNINGS

• Procoagulant effects: Tranexamic acid may cause thrombotic complications; it should be used with caution in patients at risk of such complications.

PRECAUTIONS

• General: See WARNINGS

• Laboratory Tests: No tests additional to routine ICU tests are required
• Drug/Laboratory Test Interactions: None known

IMPORTANT DRUG INTERACTIONS FOR THE ICU

• None known.

ADVERSE REACTIONS

• Body as a Whole: Allergic reactions, thrombotic events
• Cardiovascular: Hypotension (particularly with rapid injection)
• Gastrointestinal: Nausea, vomiting, diarrhoea
• Nervous System: Impaired colour vision and other visual disturbances