Tranexamic acid

Tranexamic acid

[1 vial $12.81]

ADMINISTRATION ROUTES:

  • IV

ALTERNATIVE NAMES:

  • Cyklokapron

ICU INDICATIONS:

  1. Bleeding post-cardiac surgery or other bleeding due to fibrinolysis
  2. Major trauma with significant bleeding risk

PRESENTATION AND ADMINISTRATION:

  • IV:500mg in 5ml (solution)
    Preferred method of administration is via direct IV injection at a rate of 1ml (100mg) per minute
    Can be administered by intermittent infusion by adding dose to a suitable volume of compatible IV fluid and infusing at a rate of 100mg/min
    Compatible with the following IV fluids: 0.9% sodium chloride 5% or 10% glucose Glucose and Sodium Chloride Store at room temperature. Use dilutions in IV fluid within 24 hours of preparation

DOSAGE:

  • IV: 10-25 mg/kg 8 hourly For major trauma: 1 gm over 10 mins then 1 gm over 8 hrs by infusion

DOSAGE IN RENAL FAILURE AND RENAL REPLACEMENT THERAPY:

  • Dose in renal impairment [GFR (ml/min)]:
    <10: 5mg/kg 24 hourly
    10-20: 5mg/kg 24 hourly
    >20-50: 10mg/kg 24 hourly
  • Dose in renal replacement therapy:
    CAPD: 10mg/kg 12 hourly
    HD: 10mg/kg 24 hourly
    CVVHDF: 5mg/kg 24 hourly

DOSAGE IN PAEDIATRICS:

  • IV: 10-20mg/kg 8 hourly

CLINICAL PHARMACOLOGY:

  • Tranexamic acid is an antifibrinolytic.

CONTRAINDICATIONS:

  1. previous DVT or PE
  2. hypersensitivity to tranexamic acid

WARNINGS

  • Procoagulant effects: Tranexamic acid may cause thrombotic complications; it should be used with caution in patients at risk of such complications.

PRECAUTIONS

  • General: See WARNINGS
  • Laboratory Tests: No tests additional to routine ICU tests are required
  • Drug/Laboratory Test Interactions: None known

IMPORTANT DRUG INTERACTIONS FOR THE ICU

  • None known.

ADVERSE REACTIONS

  • Body as a Whole: Allergic reactions, thrombotic events
  • Cardiovascular: Hypotension (particularly with rapid injection)
  • Gastrointestinal: Nausea, vomiting, diarrhoea
  • Nervous System: Impaired colour vision and other visual disturbances

Critical Care Drug Manual

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