[1 vial $12.55]
- IV, IM, PO
- Induction of anaesthesia
- Treatment of status epilepticus refractory to other measures (rarely used for this indication)
- Treatment of intracranial hypertension (rarely used for this indication in our ICU)
PRESENTATION AND ADMINISTRATION:
- IV: 500mg vials for reconstitution
Reconstitute with Water for Injection
For IV injection dilute 500mg to a total of 20ml using Water for Injection (makes a solution with a concentration of 25mg/ml)
Store at room temperature
- IV: 2-5mg/kg slowly stat. In unstable patients (i.e. most ICU patients) administer 75mg at a time then assess effect on blood pressure and conscious state before administering more.
DOSAGE IN RENAL FAILURE AND RENAL REPLACEMENT THERAPY:
- Dose as in normal renal function
DOSAGE IN PAEDIATRICS:
- IV: 2-5mg/kg slowly stat
- Thiopental is an ultrashort-acting depressant of the central nervous system which induces hypnosis and anesthesia, but not analgesia. It produces hypnosis within 30-40 seconds of intravenous injection. Repeated intravenous doses lead to prolonged anesthesia because fatty tissues act as a reservoir; they accumulate thiopental in concentrations 6-12 times greater than the plasma concentration, and then release the drug slowly to cause prolonged anesthesia.
- hypersensitivity to thiopentone
- acute intermittent porphyria
- Hypotension: Administer with caution in haemodynamically unstable patients
- General: Use with care in patients with reduced left ventricular function
- Laboratory Tests: No tests additional to routine ICU tests are required
- Drug/Laboratory Test Interactions: None known
IMPORTANT DRUG INTERACTIONS FOR THE ICU
- Thiopentone has a synergistic action with other CNS depressant drugs.
- Body as a Whole: Anaphylactic and anaphylactoid reactions
- Cardiovascular: Hypotension, myocardial depression, arrhythmias
- Respiratory: Respiratory depression, coughing, bronchospasm and laryngospasm
- Skin: Urticaria.