Thiamine

Thiamine

[1 vial for IV injection $30.48]

ADMINISTRATION ROUTES:

  • IV, IM, PO

ALTERNATIVE NAMES:

  • Apo thiamine, Vitamin B1

ICU INDICATIONS:

  1. Treatment / prophylaxis of vitamin B1 deficiency

PRESENTATION AND ADMINISTRATION:

  • IV/IM: 100mg in 1ml solution
    For IM administration, solution may be injected undiluted into a large muscle mass
    For IV injection, administer by direct IV slow injection over 10 minutes into a vein or the side arm of a running infusion. Can be diluted in compatible IV fluid if required. Compatible with the following IV fluids: 5% dextrose 0.9% sodium chloride
    Store at room temperature Protect from light
    Note: s29 drug when administered IV
  • PO: Tablets: Apo-thiamine 50mg tablets (white)

DOSAGE:

  • PO: Usually given in doses of 50mg for treatment of thiamine deficiency; note usual daily requirement is only 0.8-1.5mg/day
  • IV: For treatment of deficiency in ICU, usually give 100mg IV daily; for Wernickes encephalopathy give 300mg IV daily in divided doses

DOSAGE IN RENAL FAILURE AND RENAL REPLACEMENT THERAPY:

  • Dose as in normal renal function

DOSAGE IN PAEDIATRICS:

  • 1-2mg/kg IV, IM or PO daily

CLINICAL PHARMACOLOGY:

  • Vitamin B1.

CONTRAINDICATIONS:

  1. hypersensitivity to thiamine preparations

WARNINGS

  • Administration of Glucose: In patients with potential thiamine deficiency, thiamine should be administered prior to glucose even in the presence of hypoglycaemia. Thiamine is a necessary cofactor for glucose metabolism. Administration of IV glucose alone has caused permanent brain stem damage when administered to thiamine deficient patients (eg alcoholics)
  • Sensitivity reactions and intravenous use: Serious sensitivity reactions can occur. Deaths have resulted from intravenous use (use IV route with caution)

PRECAUTIONS

  • General: See WARNINGS
  • Laboratory Tests: No tests additional to routine ICU tests are required
  • Drug/Laboratory Test Interactions: None known

IMPORTANT DRUG INTERACTIONS FOR THE ICU

  • None of note

ADVERSE REACTIONS

  • General: An occasional individual may develop a sensitivity or intolerance to thiamine, especially after repeated intravenous administration. intramuscular use.
  • Skin: Pruritis, urticaria
  • Cardiovascular: Pulmonary oedema
  • Respiratory: Angioneurotic oedema
  • Gastrointestinal: Nausea, haemorrhage into the gastrointestinal tract.

Critical Care Drug Manual

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