[2mg vial $20.30]
- Opioid analgesia
PRESENTATION AND ADMINISTRATION:
- IV: Administer by intravenous infusion. Dilute 2mg in 40ml of compatible IV fluid to make a concentration of 50mcg/ml
Compatible with the following IV fluids: Water for Injection. 5% Dextrose 0.9% Sodium Chloride
- IV: Initially, 0.1-0.15mcg/kg/min; may titrate by 0.025mcg/kg/min at intervals of at least 5 minutes to desired level of analgesia or sedation; consider initiation of another sedative if desired level of sedation is not achieved with 0.2mcg/kg/min
DOSAGE IN RENAL FAILURE AND RENAL REPLACEMENT THERAPY:
- Dose as in normal renal function
DOSAGE IN PAEDIATRICS:
- IV: 0.05-0.2mcg/kg/min.
Ventilated: usually 0.5-1mcg/kg/min; occasionally up to 8mcg/min
- Remifentanil is an opioid agonist
- hypersensitivity to remifentanil
- Muscle Rigidity: At the doses recommended muscle rigidity may occur. As with other opioids, the incidence of muscle rigidity is related to the dose and rate of administration
- General: As with all potent opioids, profound analgesia is accompanied by marked respiratory depression. Due to the very rapid offset of action of remifentanil, no residual opioid activity will be present within 5-10 minutes after the discontinuation of remifentanil
Symptoms including tachycardia, hypertension and agitation have been reported upon abrupt cessation, particularly after prolonged administration of remifentanil.
- Laboratory Tests: No tests in addition to routine ICU tests are required.
Drug/Laboratory Test Interactions: None known.
IMPORTANT DRUG INTERACTIONS FOR THE ICU
- The concomitant administration with other cardiovascular depressant drugs leads to an increased risk of hypotension; concomitant administration with other CNS depressant drugs also increases the risk of CNS depression.
- Body as a Whole: Anaphylaxis
- Central nervous system: Skeletal muscle rigidity, Sedation.
- Cardiovascular system: Asystole, bradycardia, hypotension.
- Gastrointestinal system: Constipation, nausea/ vomiting.
- Respiratory system: Apnoea
- Dermatological system: Pruritis