[injection $1.75; tablets 4 cents]
- PO, IV
- Apo-Ranitidine, Zantac, Peptisoothe
PRESENTATION AND ADMINISTRATION:
Dilute 50mg dose to 20ml with compatible IV fluid and administer into side arm over at least 2 minutes.
Compatible with the following IV fluids: 0.9% sodium chloride, 5% and 10% dextrose, Glucose and Sodium Chloride, Hartmann’s
- Store at room temperature
- PO Tablets:
Apo-Ranitidine 150mg tablets (white), Arrow Ranitidine 150mg tablets (white), Zantac relief tablets (150mg)
- Oral solution:
Peptisoothe 150mg/10ml, Zantac Syrup 150mg/10ml
150mg 8-12 hourly or 300mg at night
50mg 8 hourly
DOSAGE IN RENAL FAILURE AND RENAL REPLACEMENT THERAPY:
- Dose in renal impairment [GFR (ml/min)]:
<10: 50-100% of normal dose
10-20: dose as in normal renal function
>20-50: dose as in normal renal function
- Dose in renal replacement therapy:
CAPD: 50-100% of normal dose
HD: 50-100% of normal dose
CVVHDF: dose as in normal renal function
DOSAGE IN PAEDIATRICS:
1mg/kg 8 hourly
2-4mg/kg 8-12 hourly
- Ranitidine is a selective, competitive antagonist of histamine at H2-receptor sites
- hypersensitivity to ranitidine
- General: Nil
- Laboratory Tests: No tests in addition to routine ICU tests are required.
- Drug/Laboratory Test Interactions: None known.
IMPORTANT DRUG INTERACTIONS FOR THE ICU
- None of note
- Body as a Whole: Hypersensitivity reactions (e.g. fever, bronchospasm, anaphylactic shock, rash, eosinophilia)
- Central nervous system: Malaise, dizziness, somnolence, insomnia, vertigo, mental confusion, depression and hallucinations.
- Cardiovascular system: Tachycardia, bradycardia, premature ventricular beats, A-V block and asystole.
- Gastrointestinal system: Constipation, diarrhoea, nausea/ vomiting, abdominal discomfort/ pain, hepatitis, pancreatitis. Musculoskeletal system: Rare reports of arthralgias and myalgia.
- Haematological system: Agranulocytosis or pancytopenia, sometimes with marrow hypoplasia or aplasia, have been reported.
- Dermatological system: Rash including rare cases of mild erythema multiforme. Rare cases of vasculitis have been reported.