[1 vial $4.75]
- IV, PO
PRESENTATION AND ADMINISTRATION:
10mg in 1ml (10%) solution
Add 10mg to 100ml of compatible IV fluid and administered by infusion
Compatible with the following IV fluids:
Normal saline, 5% glucose, Glucose and sodium chloride, Hartmanns
Discard any solution not used within 24 hours of preparation
Store at room temperature.
For hypotension, 100-500mcg PRN For infusion, administer by infusion at 0-60ml/hr (at higher doses, consider commencing noradrenaline)
DOSAGE IN RENAL FAILURE AND RENAL REPLACEMENT THERAPY:
- Dose as in normal renal function
DOSAGE IN PAEDIATRICS:
2-10 mcg/kg stat (adult 500mcg), then 1-5mcg/kg/min
- Phenylephrine hydrochloride is a powerful postsynaptic alpha-receptor stimulant with little effect on the beta-receptors of the heart. The predominant actions of phenylephrine hydrochloride are on the cardiovascular system.
- Hypotension solely due to low cardiac output
- Hypersensitivity to phenylephrine
- Contains sodium metabisulfite, a sulfite that may cause allergic-type reactions including anaphylactic symptoms and life-threatening or less severe asthmatic episodes in certain susceptible people. The overall prevalence of sulfite sensitivity in the general population is unknown and probably low. Sulfite sensitivity is seen more frequently in asthmatic than in nonasthmatic people.
Phenylephrine hydrochloride should be employed only with extreme caution in elderly patients or in patients with hyperthyroidism, bradycardia, partial heart block, myocardial disease, or severe arteriosclerosis.
- Laboratory Tests: No tests in addition to routine ICU tests are indicated
- Drug/Laboratory Test Interactions: None noted
IMPORTANT DRUG INTERACTIONS FOR THE ICU
- None of note
Arrhythmia (rare), decreased cardiac output, hypertension, pallor, precordial pain or discomfort, reflex bradycardia, severe peripheral and visceral vasoconstriction Central nervous system: Anxiety, dizziness, excitability, giddiness, headache, insomnia, nervousness, restlessness
- Endocrine & metabolic:
Gastric irritation, nausea
- Neuromuscular & skeletal:
Paresthesia, pilomotor response, tremor, weakness
Decreased renal perfusion, reduced urine output
Hypersensitivity reactions (including rash, urticaria, leukopenia, agranulocytosis, thrombocytopenia)