Nicotine

Nicotine [1 patch $1.76] ADMINISTRATION ROUTES:

TRANSDERMAL

ALTERNATIVE NAMES: Habitrol, Nicorette, Nicotrol

ICU INDICATIONS: 1. Nicotinewithdrawal

PRESENTATION AND ADMINISTRATION:

TD:

Habitrol 14mg/24 hours and 21mg/24 hours Apply to clean, dry, non-hairy skin on hip, chest or upper arm Store at room temperature

DOSAGE:

TD:

For patients who smoke less than 20 cigarettes per day use 14mg daily For patients who smoke less than 20 cigarettes per day use 21mg daily

DOSAGE IN RENAL FAILURE AND RENAL REPLACEMENT THERAPY: Dose as in normal renal function

DOSAGE IN PAEDIATRICS: Not applicable

CLINICAL PHARMACOLOGY: Nicotine replacement therapy

CONTRAINDICATIONS: 1. activemyocardialischaemia 2. subarachnoidhaemorrhage 3. recentcerebrovascularevent 4. generaliseddermatologicaldisorderssuchaspsoriasisorchronicdermatitis

WARNINGS Nicotine patches should be removed prior to undergoing an MRI May cause arrhythmias

PRECAUTIONS

General

Nicotine patches should be used with caution in patients with: • severe hypertension, stable angina pectoris, cerebrovascular disease, occlusive peripheral arterial disease, and heart failure. • hyperthyroidism or pheochromocytoma. • moderate to severe hepatic and/or severe renal impairment.

Nicotine

Version 30/08/2010

308Laboratory Tests:

No tests in addition to usual ICU tests are indicated

Drug/Laboratory Test Interactions:

None of note

IMPORTANT DRUG INTERACTIONS FOR THE ICU No clinically relevant interactions between NRT and other drugs have definitely been established.

ADVERSE REACTIONS

Body as a Whole:

Headache, sweating, pallor

Skin reactions:

Skin reactions consisted of erythema or pruritus at the patch site. Oedema, burning sensation, blisters, rash, or pinching at the application site were also noted. Gastrointestinal reactions: Nausea, vomiting, dyspepsia, abdominal pain, diarrhoea

Neurological System:

Abnormal dreams