Etomidate

Etomidate

[1 vial $4.09]

ADMINISTRATION ROUTES:

  • IV

ALTERNATIVE NAMES:

Etomidate

ICU INDICATIONS:

  1. induction of anaesthesia (particularly in the hypotensive patient)

PRESENTATION AND ADMINISTRATION:

  • IV:
    20mg in 10ml ampoules Inject undiluted by slow IV injection
    Store at room temperature

DOSAGE:

  • IV:
    0.3mg/kg slow IV

DOSAGE IN RENAL FAILURE AND RENAL REPLACEMENT THERAPY:

  • Dose as in normal renal function

DOSAGE IN PAEDIATRICS:

  • IV:
    0.3mg/kg slow IV

CLINICAL PHARMACOLOGY:

  • Etomidate is a hypnotic drug without analgesic activity. Intravenous injection of etomidate produces hypnosis characterized by a rapid onset of action, usually within 1 minute. Duration of hypnosis is dose dependent but relatively brief, usually 3-5 minutes when an average dose of 0.3 mg/kg is employed. Reduced cortisol plasma levels have been reported with induction doses of 0.3 mg/kg etomidate. These persist for approximately 6-8 hours and appear to be unresponsive to ACTH

CONTRAINDICATIONS

1. hypersensitivity to etomidate

WARNINGS

  • BECAUSE OF THE HAZARDS OF PROLONGED SUPPRESSION OF ENDOGENOUS CORTISOL AND ALDOSTERONE PRODUCTION, THIS FORMULATION IS NOT INTENDED FOR ADMINISTRATION BY PROLONGED INFUSION.

PRECAUTIONS

  • General:
    See WARNINGS
  • Laboratory Tests:
    No tests additional to routine ICU tests are required
  • Drug/Laboratory Test Interactions:
    None of note

IMPORTANT DRUG INTERACTIONS FOR THE ICU

  • None of note

ADVERSE REACTIONS

  • Body as a Whole:
    Anaphylaxis, adrenal suppression
  • Central Nervous System:
    myoclonus
  • Cardiovascular System:
    Hypertension, hypotension, tachycardia, bradycardia and other arrhythmias have occasionally been observed during induction and maintenance of anaesthesia
  • Respiratory System:
    Hyperventilation, hypoventilation, apnea of short duration (5-90 seconds with spontaneous recovery), laryngospasm, hiccup and snoring suggestive of partial upper airway obstruction have been observed in some patients.
  • Gastrointestinal System:
    Nausea and vomiting
  • Local:
    Pain on injection

Critical Care Drug Manual

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