Dobutamine

Dobutamine

[1 vial $65.72 ]

ADMINISTRATION ROUTES:

  • IV

ALTERNATIVE NAMES:

  • Dobutamine

ICU INDICATIONS:

  1. inotrope

PRESENTATION AND ADMINISTRATION:

  • IV:
    Each 20ml vial contains 250mg of dobutamine
    Add 250mg of dobutamine (20ml) to 80ml of compatible IV fluid (i.e. 250mg in 100ml)
    Compatible with the following IV fluids:
    Normal saline, Glucose and sodium chloride, 5% dextrose, 10% dextrose, Hartmanns
    Store at room temperature
    Protect from light

DOSAGE:

  • IV:
    Administered by infusion at rates of 2.5-20 mcg/kg/min

DOSAGE IN RENAL FAILURE AND RENAL REPLACEMENT THERAPY:

  • Dose as in normal renal function

DOSAGE IN PAEDIATRICS:

  • IV:
    15mg/kg in 50ml of 5% dextrose or normal saline at 2.5-20mcg/kg/min (0.5-4ml/hr)
    1ml/hr equals 5mcg/kg/min

CLINICAL PHARMACOLOGY:

  • Dobutamine is a direct-acting inotropic agent whose primary activity results from stimulation of the beta2-receptors of the heart while producing comparatively mild chronotropic, hypertensive, arrhythmogenic, and vasodilative effects.

CONTRAINDICATIONS

  1. idiopathic hypertrophic subaortic stenosis
  2. hypersensitivity to dobutamine

WARNINGS

  • Increase in Heart Rate or Blood Pressure:
    Dobutamine may cause a marked increase in heart rate or blood pressure, especially systolic pressure.
  • Ectopic Activity:
    Dobutamine may precipitate or exacerbate ventricular ectopic activity, but only rarely causes ventricular tachycardia.
  • Hypersensitivity:
    Reactions suggestive of hypersensitivity associated with administration of dobutamine in 5% dextrose injection, including skin rash, fever, eosinophilia, and bronchospasm, have been reported occasionally.

PRECAUTIONS

  • General:
    Hypovolemia should be corrected with suitable volume expanders before treatment with dobutamine
  • Laboratory Tests:
    No tests additional to routine ICU tests are indicated
  • Drug/Laboratory Test Interactions:
    None known.

IMPORTANT DRUG INTERACTIONS FOR THE ICU

  • None of note

ADVERSE REACTIONS

  • Cardiovascular system:
    Increased heart rate, hypotension, ventricular ectopy, atrial fibrillation, chest pain
  • Respiratory system:
    Shortness of breath
  • Gastrointestinal system:
    Nausea

Critical Care Drug Manual

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