Dobutamine

Dobutamine

[1 vial $65.72 ]

ADMINISTRATION ROUTES:

• IV

ALTERNATIVE NAMES:

• Dobutamine

ICU INDICATIONS:

1. inotrope

PRESENTATION AND ADMINISTRATION:

• IV:
  Each 20ml vial contains 250mg of dobutamine
  Add 250mg of dobutamine (20ml) to 80ml of compatible IV fluid (i.e. 250mg in 100ml)
  Compatible with the following IV fluids:
  Normal saline, Glucose and sodium chloride, 5% dextrose, 10% dextrose, Hartmanns
  Store at room temperature
  Protect from light

DOSAGE:

• IV:
  Administered by infusion at rates of 2.5-20 mcg/kg/min

DOSAGE IN RENAL FAILURE AND RENAL REPLACEMENT THERAPY:

• Dose as in normal renal function

DOSAGE IN PAEDIATRICS:

• IV:
  15mg/kg in 50ml of 5% dextrose or normal saline at 2.5-20mcg/kg/min (0.5-4ml/hr)
  1ml/hr equals 5mcg/kg/min

CLINICAL PHARMACOLOGY:

• Dobutamine is a direct-acting inotropic agent whose primary activity results from stimulation of the beta2-receptors of the heart while producing comparatively mild chronotropic, hypertensive, arrhythmogenic, and vasodilative effects.

CONTRAINDICATIONS

1. idiopathic hypertrophic subaortic stenosis
2. hypersensitivity to dobutamine

WARNINGS

• Increase in Heart Rate or Blood Pressure:
  Dobutamine may cause a marked increase in heart rate or blood pressure, especially systolic pressure.
• Ectopic Activity:
  Dobutamine may precipitate or exacerbate ventricular ectopic activity, but only rarely causes ventricular tachycardia.
• Hypersensitivity:
  Reactions suggestive of hypersensitivity associated with administration of dobutamine in 5% dextrose injection, including skin rash, fever, eosinophilia, and bronchospasm, have been reported occasionally.

PRECAUTIONS

• General:
  Hypovolemia should be corrected with suitable volume expanders before treatment with dobutamine
• Laboratory Tests:
  No tests additional to routine ICU tests are indicated
• Drug/Laboratory Test Interactions:
  None known.

IMPORTANT DRUG INTERACTIONS FOR THE ICU

• None of note

ADVERSE REACTIONS

• Cardiovascular system:
  Increased heart rate, hypotension, ventricular ectopy, atrial fibrillation, chest pain
• Respiratory system:
  Shortness of breath
• Gastrointestinal system:
  Nausea