[1 tablet 10 cents]
- acute gout
PRESENTATION AND ADMINISTRATION:
Colgout 500mcg tablets (white)
1mg then 500mcg every 6 hours until pain relief achieved or diarrhoea occurs (maximum 6mg per course and 2500mcg/24 hours; do not repeat course within 3 days)
DOSAGE IN RENAL FAILURE AND RENAL REPLACEMENT THERAPY:
- Dose in renal impairment [GFR (ml/min)]
<10: 50% of normal dose
10-20: 50% of normal dose
>20-50: dose as in normal renal function
- Dose in renal replacement therapy
CAPD: 50% of normal dose
HD: 50% of normal dose
CVVHDF: 50% of normal dose
DOSAGE IN PAEDIATRICS:
0.02mg/kg 2 hourly (maximum 3 doses per day)
- The mechanism of the relief afforded by colchicine in acute attacks of gouty arthritis is not completely known
- combined renal and hepatic impairment
- Overdose can result in irreversible multiple organ failure and death
Reduction in dosage is indicated if weakness, anorexia, nausea, vomiting or diarrhoea occurs.
- Laboratory Tests:
No tests in addition to routine ICU tests are indicated
- Drug/Laboratory Test Interactions:
IMPORTANT DRUG INTERACTIONS FOR THE ICU
- Colchicine has been shown to induce reversible malabsorption of vitamin B12, apparently by altering the function of ileal mucosa. The possibility that colchicine may increase response to central nervous system (CNS) depressants and to sympathomimetic agents is suggested by the results of experiments on animals.
- Central Nervous System:
- Musculoskeletal System:
- Gastrointestinal System:
Nausea, vomiting, abdominal pain or diarrhoea may be particularly troublesome in the presence of peptic ulcer or spastic colon.
- Hematologic System:
Aplastic anemia, agranulocytosis, or thrombocytopenia.
Dermatitis, purpura, alopecia.