[98 cents per tablet]
- secondary prevention in patients with coronary artery disease
- treatment of hypercholesterolaemia
PRESENTATION AND ADMINISTRATION:
10mg, 20mg, 40mg and 80mg strengths (white). Tablets may be crushed and adminstered via NG tube.
Commenced at 10-20mg daily at night; slowly increase to a maximum of 80mg if required.
DOSAGE IN RENAL FAILURE AND RENAL REPLACEMENT THERAPY:
- Dose as in normal renal function
DOSAGE IN PAEDIATRICS:
0.2mg/kg daily, increased every 4 weeks to a maximum of 1.6mg/kg daily.
- Atorvastatin is a selective, competitive inhibitor of HMG-CoA reductase. Atorvastatin is rapidly absorbed after oral administration; maximum plasma concentrations occur within 1-2 hours. It can be taken with or without food.
- Active liver disease or unexplained persistent elevations of serum transaminases.
- Hypersensitivity to any component of this medication.
- Liver Dysfunction:
HMG-CoA reductase inhibitors, like some other lipid-lowering therapies, have been associated with biochemical abnormalities of liver function.
- Skeletal Muscle:
Rare cases of rhabdomyolysis with acute renal failure secondary to myoglobinuria have been reported with atorvastatin and with other drugs in this class.
Patients should be advised to report promptly unexplained muscle pain, tenderness, or weakness, particularly if accompanied by malaise or fever.
- Laboratory Tests:
CK should be measured if there is concern about development of myopathy due to statins.
- Drug/Laboratory Test Interactions:
IMPORTANT DRUG INTERACTIONS FOR THE ICU
- The risk of myopathy during treatment with other drugs of this class is increased with concurrent administration of cyclosporine, fibric acid derivatives, niacin (nicotinic acid), erythromycin, and azole antifungals
- When multiple doses of atorvastatin and digoxin were coadministered, steady-state plasma digoxin concentrations increased by approximately 20%. Patients taking digoxin should be monitored appropriately.
- Body as a Whole:
- Digestive System:
Constipation, derangement of LFTs, flatulence, dyspepsia, and abdominal pain
- Nervous System:
Insomnia, dizziness, paresthesia, somnolence