Aspirin

Aspirin

[100mg enteric coated 2 cents per tablet]

ADMINISTRATION ROUTES:

  • PO, NG

ALTERNATIVE NAMES:

  • Aspec, Aspro, Cartia, Cardiprin, Disprin, Solprin

ICU INDICATIONS:

  1. antiplatelet therapy for cardiovascular and cerebrovascular disease

PRESENTATION AND ADMINISTRATION:

  • PO:
    ICU carries Disprin 300mg tablets (non-enteric coated) and Aspirin Ethics 100mg (enteric coated). Store at room temperature.

DOSAGE:

  • PO:
    For intubated patients use 1⁄2 a 300mg Disprin tablet daily crushed and administered via NG; for non-intubated patients use Aspirin Ethics 100mg (enteric coated) daily.

DOSAGE IN RENAL FAILURE AND RENAL REPLACEMENT THERAPY:

  • Dose as in normal renal function

DOSAGE IN PAEDIATRICS:

  • PO:
    Analgesia / antipyrexia:

    10-15mg/kg 4-6 hrly;
    Kawasaki:
    10mg/kg 6hrly (low dose) OR 25mg/kg 6hrly (high dose) for 2 weeks then 3-5mg/kg daily

CLINICAL PHARMACOLOGY:

  • Aspirin is a salicylate that has demonstrated antiplatelet, antiinflammatory, analgesic and antipyretic activity.

CONTRAINDICATIONS:

  1. Hypersensitivity to aspirin.
  2. Gastrointestinal bleeding.

WARNINGS

  • Subclinical GI blood loss is common; frank GI bleeding may occur

PRECAUTIONS

  • General:
    Aspirin tablets should be administered with caution to patients with asthma, nasal polyps, or nasal allergies.
  • Laboratory Tests:
    No tests in addition to routine ICU tests are indicated.
  • Drug/Laboratory Test Interactions:
    Salicylates can produce changes in thyroid function tests.

IMPORTANT DRUG INTERACTIONS FOR THE ICU

  • Oral hypoglycaemics:
    Large doses of salicylates have a hypoglycemic action and may enhance the effect of the oral hypoglycemics.
  • Phenytoin:
    Serum phenytoin levels may be increased by aspirin. Anticoagulants: Combination with other anticoagulants increases the risk of bleeding

ADVERSE REACTIONS

  • Body as a Whole:
    Headache and fever, anaphylaxis.
  • Digestive System:
    Dyspepsia, thirst, nausea, vomiting, diarrhea, acute reversible hepatotoxicity, gastrointestinal bleeding, and/or ulceration.
  • Nervous System:
    Mental confusion, drowsiness, and dizziness
  • Skin:
    Urticaria, angioedema, and pruritus.
  • Haematological System:
    Prolongation of bleeding time, leukopaenia, thrombocytopaenia, purpura, decreased plasma iron concentration and shortened erythrocyte survival time.
  • Special Senses:
    Tinnitus, vertigo, reversible hearing loss, and dimness of vision.

Critical Care Drug Manual

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