Funtabulously Frivolous Friday Five 048

• Osler’s nodules are a sign of bacterial endocarditis, which is one of the conditions comprising Osler’s triad.
• Osler’s triad is the association of pneumonia, endocarditis, and meningitis. It is an example of Stigler’s law.
• Osler’s nodules are painful indurated areas on the pads of the fingers and toes, the thenar and hypothenar eminences. They are seen in bacterial endocarditis.

• Osler, W. Infectious (so-called ulcerative) endocarditis. The Archives of Medicine, New York, 1881, 5: 44.
• Osler, W. Chronic infectious endocarditis. Quarterly Journal of Medicine, Oxford, 1908-1909, 2: 219-230.

• A syndrome of recurrent episodes of colic pain, with typical radiation to back, cold shiverings and fever; and possibly jaundice. Due to the presence in Vater’s diverticulum of a free-moving gallstone which is larger than the orifice, periodically obstructing the bile outflow in a manner similar to that of a ball-valve.
  [From WhoNamedIt]

• Osler, W. The ball-valve gallstone in the common duct. Lancet, London, 1897, I: 1319-1323.

• A technique used to detect pseudohypertension.
• In pseudohypertension the blood pressure as measured by the sphygmomanometer is artificially high because of arterial wall calcification.
• If the radial artery is compressed, yet a pulse is still palpable distally, then it is probably sclerosed.

• Hereditary hemorrhagic telangiectasia, an autosomal dominant familial syndrome characterised by multiple telangiectasia of the skin, and of the oral, nasal and gastrointestinal mucous membranes.
• In yet another example of Stigler’s law the condition was first described by Henry Gawen Sutton (1836-1891) in 1864.
• However, according to WhoNamedIt:
  “William Bart Osler… in 1901 authored the first comprehensive description of the disease, emphasizing the familial nature of the condition. Of Osler’s three patients, two came from a family in which epistaxis had appeared in seven members; both had bled at the nose from childhood, and both had numerous angiomata on the skin of the face and on the mucous membranes of the nose, lips, cheeks, and tongue. The third patient had suffered from epistaxis since the age of ten.”

• Osler, WB. On a family form of recurring epistaxis, associated with multiple telangiectases of the skin and mucous membranes. The Johns Hopkins Hospital Bulletin, 1901, 12: 333-337.

Hereditary hemorrhagic telengiectasia (click image for source) --- the mo was not described by Osler. Perhaps it was Weber?

• Nematode parasites affecting dogs (!)
• According to WhoNamedIt:
  “Osler described a previously unknown parasitic nematode among the pups at the kennels of the Montreal Hunt Club. This organism, Strongylus canis bronchialis, was renamed Filaria osleri by Thomas Spencer Cobbold in 1879, and in 1921, Oslerus osleri by Maurice Hall.”