The ‘sniff a poison’ challenge

aka Toxicology Conundrum 027

As you review a patient you notice an unusual scent about his person…

Welcome to the ‘Sniff a Poison’ Challenge!

How this works

Below is a list of odo(u)rs. For each different odour try to identify the poison(s) or toxin(s) that can give rise to it – then click on the odour (in blue) to show/hide the answer. If there are multiple answers, the number of answers listed is shown in brackets.

Start sniffing!

  • —  ammonia (its good to get off to an easy start…)
  • —  cyanide (40% of people are genetically incapable of smelling this)
  • — marijuana
    — opium 
  • — phenol
    creosote
  • nitriles
    — isopropyl alcohol
    — ketoacidosis
    — lacquer
    — ethanol
    — isopropanol
    — chloroform
    trichloroethane
    paraldehyde
    — chloral hydrate
    methylbromide
    — nitrites (amyl, butyl) 
  • phosphorus
    tellurium
    — inorganic arsenicals and arsine gas
    — organophosphates
    — selenium
    — thallium
    — dimethyl sulfoxide (DMSO)
  • — zinc phosphide
    — aluminum phosphide
    nickel carbonyl
  • — phosgene 
  • — methylsalicylate (Oil of Wintergreen)
    — menthol 
  • — napthalene
    — camphor
    — p-dichlorobenzene 
  • — chloral hydrate
  • — o-chlorobenzylidene malonitrile (CS or tear gas)
  • — pine oil 
  • — Hydrogen sulfide
    (olfactory fatigue occurs after about 15 minutes at the potentially toxic level of 50 ppm. This happens even faster at higher concentrations – so the victim is at least spared the stench of rotten eggs…)
    carbon disulfide
    — mercaptans
    — disulfiram
    — N-acetylcysteine (antidote)
  • —  nitrobenzene
  • —  nicotine! 
  • —  acetic acid
    — hydrofluoric acid 
  • — turpentine (urinary metabolites)

The bonus question:

A bite by which Australian snake could seriously impair your performance on the ‘Sniff a Poison’ challenge?

Potentially any of them!

However, at least one species can specifically impair the victim’s sense of smell: the Red-bellied Black Snake, Pseudechis porphyriacus, one of Australia’s most striking and beautiful snakes.

The sniff a poison challenge Red bellied black snake

Red-bellied Black Snake (photo by webboydotnet)

Victims may experience permanent alterations in their olfactory sense. Abnormalities include anosmia (loss of smell), cacosmia (the sensation of a foul smell – not good), dysosmia (a distorted perception of smell) and even phantosmia (the sensation of smell without stimulus).

References

  • Flomenbaum N, et al (2006). Goldfrank’s Toxicologic Emergencies (8th edition). McGraw-Hill Professional.
  • Sutherland SK, Tibballs J (2001). Australian animal toxins: the creatures, their toxins and care of the poisoned patient (2nd edition). Oxford University Press.

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About Chris Nickson

An oslerphile suffering from a bad case of knowledge dipsosis. Key areas of interest include: emergency medicine, critical care, toxicology, tropical medicine, clinical epidemiology, history, literature and the internet-learning revolution. @precordialthump | + Chris Nickson | Contact

Comments

  1. nice post..this stuff is asked a lot in competitive exams in India..

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